SUBCLINICAL HYPOTHYROIDISM IN INFERTILE WOMEN
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Keywords
Subclinical hypothyroidism, Infertility, Thyroid dysfunction
Abstract
Objective: To study the prevalence of subclinical hypothyroidism in infertile women.
Methodology: This cross sectional study was conducted on 151 married infertile women, attending the out-patient department of Jinnah Medical College hospital Karachi in duration of three months between March 1, 2021 and May 31, 2021.
Related history was taken; Serum TSH, T3 and T4 levels were calculated by using enzyme immune assay on ELISA reader. All information was recorded on a pre-designed data collection sheet. The normal ranges of our laboratory for TSH, T3 and T4 were taken as0.27-4.2 µIU/ml, 0.8-2 ng/dl and 4.8-12.7µg/dl respectively.
Results: The average age of the women was 29.13±6.20 years. The Prevalence of subclinical hypothyroidism in infertile women was found to be 34.81%. Higher prevalence was seen in cases with secondary infertility (59.5%) as compared to those with primary infertility (40.4%). Regarding thyroid profile, the mean serum T3 levels were found to be 1.56 ng/ml (with std of 0.870), mean T4 levels were 2.41µg/dl (with std of 1.003) and mean TSH levels were 2.89 μIU/ml (with std of 3.036). The correlation of BMI with subclinical hypothyroidism, it was seen that 74.5% of cases with subclinical hypothyroidism had BMI >25 kg/m2.
Conclusion: - We found Sub-clinical hypothyroidism as an important cause of infertility. Women with infertility constitute a selected group of patients for whom systematic screening for thyroid disorders should be performed. When thyroid dysfunction is detected, treatment is able to restore normal fertility and reduce the likelihood of an Assisted Reproductive Technology procedure.
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Dr. Syeda Fariha Hussain
Assistant Professor, Gynae and Obs department, Jinnah Medical and Dental College, Karachi
Dr. Shazia Aftab
Professor, Gynae and Obs department, Jinnah Medical and Dental College, Karachi
Dr. Misbah Aziz
Senior Registrar, Gynae and Obs department, Jinnah Medical and Dental College, Karachi
Dr. Zakia Bano
Assistant Professor, Gynae and Obs department, Liaquat College of Medicine and Dentistry, Karachi
Dr. Erum Memon
Assistant Professor, Gynae and Obs department, Jinnah Medical and Dental College, Karachi
Dr. Shagufta Naqvi
Assistant Professor, Community Medicine department, Jinnah Medical and Dental College, Karachi