PROMOTING SLEEP HEALTH WITH HERBAL TEA: DEVELOPMENT, EVALUATION, AND ANXIOLYTIC EFFECTS
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Abstract
Insomnia, a widespread issue in modern life characterized by sleep difficulties, has prompted interest in herbal remedies known for their calming effects. This study explores the potential of a herbal tea formulation containing Passiflora incarnata L. (PI), Valeriana officinalis (valerian), and Chamomilla matricaria extracts as a solution for insomnia. Microscopic examination validated the authenticity of the herbal components, while extracts were prepared through meticulous maceration and evaporation. Safety analysis, assessing lethal dose (LD50), confirmed the tea's safety with an LD50 of 2400 mg/kg.In an animal study involving thiopental sodium-induced sleep in mice, significant findings emerged. The test group receiving the herbal tea at 300 mg/kg and 500 mg/kg exhibited notably shorter sleep onset times (p < 0.05) compared to the control group. Additionally, their sleep duration at these doses significantly exceeded that of the control group (p < 0.01). These results collectively suggest that the herbal tea, especially at doses of 300 mg/kg and 500 mg/kg, exhibited an anxiolytic effect, as evidenced by increased open-arm exploration and reduced anxiety-like behavior in the Elevated Plus Maze (EPM) test. These findings highlight the herbal tea's potential as a safe and effective sleep aid, offering promise in addressing insomnia. However, further research is necessary to explore its clinical applications in humans, advancing our understanding of its broader therapeutic potential for sleep-related issues.
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Dr. Mehwish Khan
Faculty of Pharmacy; Department of Pharmacognosy, Jinnah University for women Karachi Pakistan
Dr. Nudrat Fatima
Faculty of Pharmaceutical sciences, Ziauddin college of Pharmacy Karachi Pakistan
Dr. Asma Wazir
Faculty of Pharmacy, Department of Pharmacognosy, Federal Urdu University of science and technology Karachi Pakistan
Dr. Zuneera Akram
Faculty of Baqai Institute of Pharmaceutical sciences, Department of Pharmacology, Baqai Medical University Karachi Pakistan
Dr. Hina Rehman Ansari
Faculty of Pharmacy, Department of Pharmacy Practice, Jinnah Sindh medical University Karachi Pakistan
Dr. Fatima Qamar
Faculty of Pharmacy; Department of Pharmaceutical chemistry, Jinnah University for women Karachi Pakistan