FORMULATION AND EVALUATION OF SELF-NANOEMULSIFYING DUAL DRUG DELIVERY SYSTEM OF CELECOXIB AND CURCUMIN.
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Keywords
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Abstract
The goal of this research is to create new lipid-based SNEDDS (self-nanoemulsifying drug delivery systems) Celecoxib & Curcumin. A Sonication method was used to determine the solubility in equilibrium of celecoxib and curcumin in various oils and other components Surfactants (Tween-20, Tween-80, Span-20, Span-80) and cosurfactants (Polyethylene glycol-400, Isopropyl alcohol, Glycerol) and water. Solubility, partition coefficient and compatibility tests were evaluated. The formulation was evaluated for optical clarity, phase separation study, Analysis of globular size, self-emulsification time, and zeta potential electrophoretic mobility & transmission electron microscopy (TEM). Form invitro dissolution study % cumulative release of celecoxib and curcumin is more when comparing SGF to SIF (simulated gastric fluid to simulated intestinal fluid).
References
1. Chen, L., et al., Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 2018. 9(6): p. 7204-7218.
2. Megha, K.B., et al., Cascade of immune mechanism and consequences of inflammatory disorders. Phytomedicine, 2021. 91: p. 153712.
3. Bennett, J.M., et al., Inflammation–Nature's Way to Efficiently Respond to All Types of Challenges: Implications for Understanding and Managing “the Epidemic” of Chronic Diseases. Frontiers in Medicine, 2018. 5.
4. Marshall, J.S., et al., An introduction to immunology and immunopathology. Allergy, Asthma & Clinical Immunology, 2018. 14(2): p. 49.
5. Zigterman, B.G.R. and L. Dubois, [Inflammation and infection: cellular and biochemical processes]. Ned Tijdschr Tandheelkd, 2022. 129(3): p. 125-129.
6. Pahwa, R., A. Goyal, and I. Jialal, Chronic Inflammation, in StatPearls. 2023, StatPearls Publishing Copyright © 2023, StatPearls Publishing LLC.: Treasure Island (FL) ineligible companies. Disclosure: Amandeep Goyal declares no relevant financial relationships with ineligible companies. Disclosure: Ishwarlal Jialal declares no relevant financial relationships with ineligible companies.
7. Furman, D., et al., Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 2019. 25(12): p. 1822-1832.
8. Buer, J.K., Origins and impact of the term ‘NSAID’. Inflammopharmacology, 2014. 22(5): p. 263-267.
9. Westbrook, A.M., A. Szakmary, and R.H. Schiestl, Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models. Mutat Res, 2010. 705(1): p. 40-59.
10. Kendall, M.J., S. Nutter, and C.F. Hawkins, Xylose test: effect of aspirin and indomethacin. Br Med J, 1971. 1(5748): p. 533-6.
11. Shin, S.J., et al., Non-steroidal anti-inflammatory drug-induced enteropathy. Intest Res, 2017. 15(4): p. 446-455.
12. Adebayo, D. and I. Bjarnason, Is non-steroidal anti-inflammaory drug (NSAID) enteropathy clinically more important than NSAID gastropathy? Postgrad Med J, 2006. 82(965): p. 186-91.
13. Sohail, R., et al., Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review. Cureus, 2023. 15(4): p. e37080.
14. Coutinho, A.E. and K.E. Chapman, The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol, 2011. 335(1): p. 2-13.
15. Green, G.A., Understanding NSAIDs: From aspirin to COX-2. Clinical Cornerstone, 2001. 3(5): p. 50-59.
16. Davis, A. and J. Robson, The dangers of NSAIDs: look both ways. British Journal of General Practice, 2016. 66(645): p. 172-173.
17. Dannhardt, G. and W. Kiefer, Cyclooxygenase inhibitors – current status and future prospects. European Journal of Medicinal Chemistry, 2001. 36(2): p. 109-126.
18. Cruz, J.V., et al., The Role of Celecoxib as a Potential Inhibitor in the Treatment of Inflammatory Diseases - A Review. Current Medicinal Chemistry, 2022. 29(17): p. 3028-3049.
19. Woo, W.-M., Skin Structure and Biology, in Imaging Technologies and Transdermal Delivery in Skin Disorders. 2019. p. 1-14.
20. Kruglikov, I.L. and P.E. Scherer, Skin aging as a mechanical phenomenon: The main weak links. Nutrition and Healthy Aging, 2018. 4: p. 291-307.
21. Wong, R., et al., The dynamic anatomy and patterning of skin. Experimental Dermatology, 2016. 25(2): p. 92-98.
22. Celleno, L. and F. Tamburi, Chapter 1 - Structure and Function of the Skin, in Nutritional Cosmetics, A. Tabor and R.M. Blair, Editors. 2009, William Andrew Publishing: Boston. p. 3-45.
23. Kadam, S., D. Shinkar, and R. Saudagar, Review on solubility enhancement techniques. IJPBS, 2013. 3(3): p. 462-75.
24. Donsì, F. and K.P. Velikov, Chapter Two - Encapsulation of food ingredients by single O/W and W/O nanoemulsions, in Lipid-Based Nanostructures for Food Encapsulation Purposes, S.M. Jafari, Editor. 2019, Academic Press. p. 37-87.
25. Chime, S.A., F.C. Kenechukwu, and A.A. Attama, Nanoemulsions — Advances in Formulation, Characterization and Applications in Drug Delivery, in Application of Nanotechnology in Drug Delivery, S. Ali Demir, Editor. 2014, IntechOpen: Rijeka. p. Ch. 3.
26. Rajpoot, P., K. Pathak, and V. Bali, Therapeutic Applications of Nanoemulsion Based Drug Delivery Systems: A Review of Patents in Last Two Decades. Recent Patents on Drug Delivery & Formulation, 2011. 5(2): p. 163-172.
27. Rehman, F.U., et al., From nanoemulsions to self-nanoemulsions, with recent advances in self-nanoemulsifying drug delivery systems (SNEDDS). Expert Opinion on Drug Delivery, 2017. 14(11): p. 1325-1340.
28. Choradiya, B.R. and S.B. Patil, A comprehensive review on nanoemulsion as an ophthalmic drug delivery system. Journal of Molecular Liquids, 2021. 339: p. 116751.
29. Mundada, V., M. Patel, and K. Sawant, Submicron Emulsions and Their Applications in Oral Delivery. 2016. 33(3): p. 265-308.
30. Akhlaquer Rahman, M., et al., Oral Lipid Based Drug Delivery System (LBDDS): Formulation, Characterization and Application: A Review. Current Drug Delivery, 2011. 8(4): p. 330-345.
31. Zhang, L., et al., Self-emulsifying drug delivery system and the applications in herbal drugs. Drug Delivery, 2015. 22(4): p. 475-486.
32. Hörmann, K. and A. Zimmer, Drug delivery and drug targeting with parenteral lipid nanoemulsions — A review. Journal of Controlled Release, 2016. 223: p. 85-98.
33. Sutradhar, K.B. and M.L. Amin, Nanoemulsions: increasing possibilities in drug delivery. 2013. 5(2): p. 97-110.
34. Biermann, U., et al., Oils and Fats as Renewable Raw Materials in Chemistry. Angewandte Chemie International Edition, 2011. 50(17): p. 3854-3871
2. Megha, K.B., et al., Cascade of immune mechanism and consequences of inflammatory disorders. Phytomedicine, 2021. 91: p. 153712.
3. Bennett, J.M., et al., Inflammation–Nature's Way to Efficiently Respond to All Types of Challenges: Implications for Understanding and Managing “the Epidemic” of Chronic Diseases. Frontiers in Medicine, 2018. 5.
4. Marshall, J.S., et al., An introduction to immunology and immunopathology. Allergy, Asthma & Clinical Immunology, 2018. 14(2): p. 49.
5. Zigterman, B.G.R. and L. Dubois, [Inflammation and infection: cellular and biochemical processes]. Ned Tijdschr Tandheelkd, 2022. 129(3): p. 125-129.
6. Pahwa, R., A. Goyal, and I. Jialal, Chronic Inflammation, in StatPearls. 2023, StatPearls Publishing Copyright © 2023, StatPearls Publishing LLC.: Treasure Island (FL) ineligible companies. Disclosure: Amandeep Goyal declares no relevant financial relationships with ineligible companies. Disclosure: Ishwarlal Jialal declares no relevant financial relationships with ineligible companies.
7. Furman, D., et al., Chronic inflammation in the etiology of disease across the life span. Nature Medicine, 2019. 25(12): p. 1822-1832.
8. Buer, J.K., Origins and impact of the term ‘NSAID’. Inflammopharmacology, 2014. 22(5): p. 263-267.
9. Westbrook, A.M., A. Szakmary, and R.H. Schiestl, Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models. Mutat Res, 2010. 705(1): p. 40-59.
10. Kendall, M.J., S. Nutter, and C.F. Hawkins, Xylose test: effect of aspirin and indomethacin. Br Med J, 1971. 1(5748): p. 533-6.
11. Shin, S.J., et al., Non-steroidal anti-inflammatory drug-induced enteropathy. Intest Res, 2017. 15(4): p. 446-455.
12. Adebayo, D. and I. Bjarnason, Is non-steroidal anti-inflammaory drug (NSAID) enteropathy clinically more important than NSAID gastropathy? Postgrad Med J, 2006. 82(965): p. 186-91.
13. Sohail, R., et al., Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review. Cureus, 2023. 15(4): p. e37080.
14. Coutinho, A.E. and K.E. Chapman, The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol, 2011. 335(1): p. 2-13.
15. Green, G.A., Understanding NSAIDs: From aspirin to COX-2. Clinical Cornerstone, 2001. 3(5): p. 50-59.
16. Davis, A. and J. Robson, The dangers of NSAIDs: look both ways. British Journal of General Practice, 2016. 66(645): p. 172-173.
17. Dannhardt, G. and W. Kiefer, Cyclooxygenase inhibitors – current status and future prospects. European Journal of Medicinal Chemistry, 2001. 36(2): p. 109-126.
18. Cruz, J.V., et al., The Role of Celecoxib as a Potential Inhibitor in the Treatment of Inflammatory Diseases - A Review. Current Medicinal Chemistry, 2022. 29(17): p. 3028-3049.
19. Woo, W.-M., Skin Structure and Biology, in Imaging Technologies and Transdermal Delivery in Skin Disorders. 2019. p. 1-14.
20. Kruglikov, I.L. and P.E. Scherer, Skin aging as a mechanical phenomenon: The main weak links. Nutrition and Healthy Aging, 2018. 4: p. 291-307.
21. Wong, R., et al., The dynamic anatomy and patterning of skin. Experimental Dermatology, 2016. 25(2): p. 92-98.
22. Celleno, L. and F. Tamburi, Chapter 1 - Structure and Function of the Skin, in Nutritional Cosmetics, A. Tabor and R.M. Blair, Editors. 2009, William Andrew Publishing: Boston. p. 3-45.
23. Kadam, S., D. Shinkar, and R. Saudagar, Review on solubility enhancement techniques. IJPBS, 2013. 3(3): p. 462-75.
24. Donsì, F. and K.P. Velikov, Chapter Two - Encapsulation of food ingredients by single O/W and W/O nanoemulsions, in Lipid-Based Nanostructures for Food Encapsulation Purposes, S.M. Jafari, Editor. 2019, Academic Press. p. 37-87.
25. Chime, S.A., F.C. Kenechukwu, and A.A. Attama, Nanoemulsions — Advances in Formulation, Characterization and Applications in Drug Delivery, in Application of Nanotechnology in Drug Delivery, S. Ali Demir, Editor. 2014, IntechOpen: Rijeka. p. Ch. 3.
26. Rajpoot, P., K. Pathak, and V. Bali, Therapeutic Applications of Nanoemulsion Based Drug Delivery Systems: A Review of Patents in Last Two Decades. Recent Patents on Drug Delivery & Formulation, 2011. 5(2): p. 163-172.
27. Rehman, F.U., et al., From nanoemulsions to self-nanoemulsions, with recent advances in self-nanoemulsifying drug delivery systems (SNEDDS). Expert Opinion on Drug Delivery, 2017. 14(11): p. 1325-1340.
28. Choradiya, B.R. and S.B. Patil, A comprehensive review on nanoemulsion as an ophthalmic drug delivery system. Journal of Molecular Liquids, 2021. 339: p. 116751.
29. Mundada, V., M. Patel, and K. Sawant, Submicron Emulsions and Their Applications in Oral Delivery. 2016. 33(3): p. 265-308.
30. Akhlaquer Rahman, M., et al., Oral Lipid Based Drug Delivery System (LBDDS): Formulation, Characterization and Application: A Review. Current Drug Delivery, 2011. 8(4): p. 330-345.
31. Zhang, L., et al., Self-emulsifying drug delivery system and the applications in herbal drugs. Drug Delivery, 2015. 22(4): p. 475-486.
32. Hörmann, K. and A. Zimmer, Drug delivery and drug targeting with parenteral lipid nanoemulsions — A review. Journal of Controlled Release, 2016. 223: p. 85-98.
33. Sutradhar, K.B. and M.L. Amin, Nanoemulsions: increasing possibilities in drug delivery. 2013. 5(2): p. 97-110.
34. Biermann, U., et al., Oils and Fats as Renewable Raw Materials in Chemistry. Angewandte Chemie International Edition, 2011. 50(17): p. 3854-3871
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Mar 16, 2023
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Shubham Singh, & Dr. Jai Narayan Mishra. (2023). FORMULATION AND EVALUATION OF SELF-NANOEMULSIFYING DUAL DRUG DELIVERY SYSTEM OF CELECOXIB AND CURCUMIN. Journal of Population Therapeutics and Clinical Pharmacology, 30(4), 726-740. https://doi.org/10.53555/jptcp.v30i4.2845
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Author Biographies
Shubham Singh
Research scholar Kailash Institute of Pharmacy and Management, Gida Gorakhpur Uttar Pradesh
Dr. Jai Narayan Mishra
director Kailash institute of pharmacy and management Gida Gorakhpur Uttar Pradesh
How to Cite
Shubham Singh, & Dr. Jai Narayan Mishra. (2023). FORMULATION AND EVALUATION OF SELF-NANOEMULSIFYING DUAL DRUG DELIVERY SYSTEM OF CELECOXIB AND CURCUMIN. Journal of Population Therapeutics and Clinical Pharmacology, 30(4), 726-740. https://doi.org/10.53555/jptcp.v30i4.2845