LIPIDOMIC ANALYSIS OF OMEGA-3 FATTY ACIDS IMPLICATIONS FOR CARDIOVASCULAR HEALTH- A DETAILED STUDY ON THE BENEFICIAL EFFECTS OF OMEGA-3 FATTY ACIDS
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Keywords
BMI, HDL, RCT, Omega-3, Fatty Acids, CVD, Patients
Abstract
Introduction: Cardiovascular health stands as a paramount concern in contemporary medicine and public health. The prevalence of cardiovascular diseases (CVDs) and their associated risk factors continue to pose a substantial burden on global healthcare systems and overall well-being.
Objectives: The basic aim of the study is to find the lipidomic analysis of omega-3 fatty acids and its implications for cardiovascular health as a detailed study on the beneficial effects of omega-3 fatty acids.
Material and methods: This Randomized Controlled Trial (RCT) was conducted in Mohtarma Benazir Bhutoo Shaheed Medical College Mirpur AJK from January 2023 to June 2023. A total of 220 adult participants was added in the study. Data collection in this randomized controlled trial (RCT) involves a comprehensive and systematic approach to gather a wide range of information essential for assessing the impact of omega-3 fatty acid supplementation on cardiovascular health.
Results: The study included 220 adult participants, evenly distributed between the treatment (omega-3 supplementation) and control (placebo) groups, with an average age of 50 years and a balanced gender distribution. Approximately 60% of participants in both groups had a history of hypertension at baseline. Elevated cholesterol levels (LDL cholesterol ≥ 130 mg/dL) were observed in 45% of participants in both groups. About 30% of participants had a family history of cardiovascular diseases. 20% of participants in both groups reported a history of smoking. The average BMI was 28 kg/m², indicating a generally overweight population.
Conclusion: It is concluded that this study provides valuable insights into the potential cardiovascular benefits of omega-3 fatty acid supplementation, including reductions in blood pressure, favorable lipidomic changes, and shifts towards an anti-inflammatory state.
References
2. Madsen CM, Varbo A, Nordestgaard BG. Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies. Eur Heart J. (2017) 32:2478–86. 10.1093/eurheartj/ehx163
3. Lombardi M, Chiabrando JG, Vescovo GM, Bressi E, Del Buono MG, Carbone S, et al.. Impact of different doses of omega-3 fatty acids on cardiovascular outcomes: a pairwise and network meta-analysis. Curr Atheroscler Rep. (2020) 22:45. 10.1007/s11883-020-00865-5
4. Hu Y, Hu FB, Manson JE. Marine omega-3 supplementation and cardiovascular disease: an updated meta-analysis of 13 randomized controlled trials involving 127 477 participants. J Am Heart Assoc. (2019) 8:19. 10.1161/JAHA.119.013543
5. Rizos EC, Markozannes G, Tsapas A, Mantzoros CS, Ntzani EE. Omega-3 supplementation and cardiovascular disease: formulation-based systematic review and meta-analysis with trial sequential analysis. Heart. (2021) 107:150–8. 10.1136/heartjnl-2020-316780
6. Handelsman Y, Shapiro MD. Triglycerides, atherosclerosis, and cardiovascular outcome studies: focus on omega-3 fatty acids. Endocr Pract. (2017) 23:100–12. 10.4158/EP161445.RA
7. Abdelhamid AS, Brown TJ, Brainard JS, Biswas P, Thorpe GC, Moore HJ, et al.. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. (2020) 3:CD003177. 10.1002/14651858.CD003177.pub5
8. Raposo HF, Patrício PR, Simões MC, Oliveira HCF. Fibrates and fish oil, but not corn oil, up-regulate the expression of the cholesteryl ester transfer protein (CETP) gene. J Nutr Biochem. (2014) 25:669–74. 10.1016/j.jnutbio.2014.02.008
9. Laurinavicius AG, Santos IS, Santos RD, Bensenor IM, Conceição RD, Lotufo PA. Extremely elevated HDL-cholesterol levels are not associated with increased carotid intima-media thickness: data from ELSA Brasil. J Clin Lipidol. (2016) 10:898–904. 10.1016/j.jacl.2016 .03.007
10. Kontush A, Chapman MJ. Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities. Curr Opin Lipidol. (2010) 21:312–8. 10.1097/MOL.0b013e32833bc dc1
11. Allaire J, Couture P, Leclerc M, Charest A, Marin J, Lépine MC, et al.. A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the comparing EPA to DHA (ComparED) study. Am J Clin Nutr. (2016) 104:280–7. 10.3945/ajcn.116.131896
12. Jun M, Foote C, Lv J, Neal B, Patel A, Nicholls SJ, Grobbee DE, Cass A, Chalmers J, Perkovic V. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet. 2010; 375:1875–1884.
13. Rischio and Prevenzione Investigators. Efficacy of n-3 polyunsaturated fatty acids and feasibility of optimizing preventive strategies in patients at high cardiovascular risk: rationale, design and baseline characteristics of the Rischio and Prevenzione study, a large randomised trial in general practice. Trials. 2010; 11:68.
14. Wei MY, Jacobson TA. Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. Curr Atheroscler Rep. (2011) 13:474–83. 10.1007/s11883-011-0210-3
15. Augustine AH, Lowenstein LM, Harris WS, Shearer GC, Block RC. Treatment with omega-3 fatty acid ethyl-ester alters fatty acid composition of lipoproteins in overweight or obese adults with insulin resistance. Prostaglandins Leukot Essent Fatty Acids. (2014) 90:69–75. 10.1016/j.plefa.2013.12.003
16. Kontush A, Lindahl M, Lhomme M, Calabresi L, Chapman MJ, Davidson WS. Structure of HDL: particle subclasses and molecular components. Handb Exp Pharmacol. (2015) 224:3–51. 10.1007/978-3-319-09665-0_1
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Dr Muhammad Shahbaz
Pakistan Institute of Medical Sciences
Dr Muhammad Amir
Akbar Niazi Teaching Hospital
Dr Sabeen Islam
Pakistan Institute of Medical Sciences
Dr Asnad
Associate Professor of Biochemistry Mohtarma Benazir Bhutoo Shaheed Medical College Mirpur AJK