PREVALENCE OF NEUROPATHIC COMPONENT IN POST-COVID PAIN SYMPTOMS IN PREVIOUSLY HOSPITALIZED COVID-19 SURVIVORS

Main Article Content

Dr. Lareb Gul
Malik Talha Saad
FNU Anam
Dr. Muhammad Ayoob Memon
Dr Amna Malik
Dr Ali Karim
FNU Simran
Sheena kumari
Mohsin Ali
FNU Partab

Keywords

COVID-19, Pain Symptoms, Survivors, global health, syndrome

Abstract

Background: This structured abstract provides a summary of the literature review conducted to investigate the prevalence of the neuropathic component in post-COVID pain symptoms among previously hospitalized COVID-19 survivors.


Methods: A comprehensive literature search was conducted using electronic databases, including PubMed, Google Scholar, and relevant medical journals. Studies focusing on the neuropathic component in post-COVID pain symptoms among COVID-19 survivors were included in the review. Data extraction and analysis were performed to identify common themes and research gaps.


Results: The literature review revealed a limited number of studies specifically examining the prevalence, characteristics, and management of neuropathic pain in post-COVID patients. The available literature mainly focused on the acute phase and immediate complications of COVID-19, overlooking the long-term consequences, including chronic pain. The absence of standardized assessment tools specific to neuropathic pain further hindered the accurate diagnosis and evaluation of neuropathic pain symptoms.


Conclusion: The literature review identified significant research gaps regarding the neuropathic component in post-COVID pain symptoms among previously hospitalized COVID-19 survivors. Further research is needed to address these gaps and improve the understanding, diagnosis, and management of neuropathic pain in this population.

Abstract 453 | pdf Downloads 120

References

1. Huang Q, Zhao Y, Gong N, et al. Neuropathic pain in patients after recovery from COVID-19. Pain Pract. 2021;21(5):523-525.
2. Helms J, Kremer S, Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection. N Engl J Med. 2020;382(23):2268-2270.
3. Needham DM, Davidson J, Cohen H, et al. Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference. Crit Care Med. 2012;40(2):502-509.
4. Hachem LD, Mansfield KE, Patel VM, et al. Persistent hyperinflammation and Long COVID: mechanisms and management. Front Immunol. 2022;13:791212.
5. Donnelly SC, Hasleton PS, Mackenzie IJ, et al. Idiopathic pulmonary fibrosis: usual interstitial pneumonia adjacent to bronchiolar metaplasia and cellular bronchiolitis. Histopathology. 1998;33(3):242-247.
6. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-733.
7. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-1242.
8. Nijs, Jo, et al. "Phenotyping Post-COVID Pain as a Nociceptive, Neuropathic, or Nociplastic Pain Condition." Biomedicines, vol. 10, no. 10, 2022, p. 2562, https://doi.org/10.3390/biomedicines10102562.
9. Fernández-de-las-Peñas, C.; Navarro-Santana, M.; Plaza-Manzano, G.; Palacios-Ceña, D.; Arendt-Nielsen, L. Time course prevalence of Post-COVID pain symptoms of musculoskeletal origin in patients who had survived to SARS-CoV-2 infection: A systematic review and meta-analysis. Pain 2022, 163, 1220–1231.
10. Soares, F.H.C.; Kubota, G.T.; Fernandes, A.M.; Hojo, B.; Couras, C.; Costa, B.V.; Lapa, J.D.D.S.; Braga, L.M.; Almeida, M.M.; Cunha, P.H.M.D.; et al. “Pain in the Pandemic Initiative Collaborators”. Prevalence and characteristics of new-onset pain in COVID-19 survivours, a controlled study. Eur. J. Pain 2021, 25, 1342–1354.
11. Smart, K.M.; Blake, C.; Staines, A.; Doody, C. Clinical indicators of “nociceptive”, “peripheral neuropathic” and “central” mechanisms of musculoskeletal pain. A Delphi survey of expert clinicians. Man. Ther. 2010, 15, 80–87.
12. César Fernández-de-las-Peñas, Dr. Med, PhD and others, Development of Neuropathic Post-COVID Pain Symptoms Is Not Associated with Serological Biomarkers at Hospital Admission in COVID-19 Survivors: A Secondary Analysis, Pain Medicine, Volume 23, Issue 12, December 2022, Pages 2092–2094, https://doi.org/10.1093/pm/pnac086
13. Nijs, Jo, et al. "Precision Management of Post-COVID Pain: An Evidence and Clinical-Based Approach." European Journal of Pain, https://doi.org/10.1002/ejp.2095.
14. Torices, S.; Cabrera, R.; Stangis, M.; Naranjo, O.; Fattakhov, N.; Teglas, T.; Adesse, D.; Toborek, M. Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: Implications for HIV-1 infection. J. Neuroinflamm. 2021, 18, 167
15. Herrero-Montes, M.; Fernández-de-las-Peñas, C.; Ferrer-Pargada, D.; Tello-Mena, S.; Cancela-Cilleruelo, I.; Rodríguez-Jiménez, J.; Palacios-Ceña, D.; Parás-Bravo, P. Prevalence of neuropathic component in post-COVID pain symptoms in previously hospitalized COVID-19 survivors. Int. J. Clin. Pract. 2022, 2022, 3532917
16. Fitzcharles, M.A.; Cohen, S.P.; Clauw, D.J.; Littlejohn, G.; Usui, C.; Häuser, W. Nociplastic pain: Towards an understanding of prevalent pain conditions. Lancet 2021, 397, 2098–2110.
17. Jimeno-Almazán, A.; Pallarés, J.G.; Buendía-Romero, Á.; Martínez-Cava, A.; Franco-López, F.; Sánchez-Alcaraz Martínez, B.J.; Bernal-Morel, E.; Courel-Ibáñez, J. Post-COVID-19 syndrome and the potential benefits of exercise. Int. J. Environ. Res. Public Health 2021, 18, 5329
18. Cattadori, G.; Di Marco, S.; Baravelli, M.; Picozzi, A.; Ambrosio, G. Exercise training in post-COVID-19 patients: The need for a multifactorial protocol for a multifactorial pathophysiology. J. Clin. Med. 2022, 11, 2228.
19. Bailly, M.; Pélissier, L.; Coudeyre, E.; Evrard, B.; Bingula, R.; Rochette, C.; Mériade, L.; Blavignac, C.; Fournier, A.C.; Bignon, Y.J.; et al. Systematic review of COVID-19-related physical activity-based rehabilitations: Benefits to be confirmed by more robust methodological approaches. Int. J. Environ. Res. Public Health 2022, 19, 9025
20. Bodes-Pardo, G.; Lluch-Girbés, E.; Roussel, N.A.; Gallego-Izquierdo, T.; Jiménez-Penick, V.; Pecos-Martín, D. Pain neurophysiology education and therapeutic exercise for patients with chronic low back pain: A single-blind randomized controlled trial. Arch. Phys. Med. Rehabil. 2018, 99, 338–347

Most read articles by the same author(s)