INSILICO, SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL QUINOLINE DERIVATIVES
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Keywords
Quinolines, DNA Gyrase, p-Hydroxy benzaldehyde, Sodium acetate, Potassium hydroxide, Choroacetyl chloride, Choropropionyl chloride, Antimicrobial activity
Abstract
The purpose of this research is to functionalize to synthesise 4,7-disubstituted quinoline.Intially quinoline derivatives was docked using3U2D DNA Gyrase as a target for anti-bacterial activity by using schrodinger software, from the results obtained from docking only those compounds which shown potent activity were subjected for synthesis using facile method.The synthesized compounds wascharacterized by IR, NMR and Mass spectrometry,
The synthesized compounds (TM1-TM8) were screened for antibacterial activity studies at various concentrations of 5, 10, 25, 50 and 75mg/ml using DMF as a control against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Klebsiella pneumonia, by agar-well diffusion method. Ciprofloxacin was used as standard drug.
Among the synthesized compounds TM4shown moderate activity when compared with the standard, rest of the derivatives possesses weak antibacterial activity.
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Arti J.Darode
Nagpur College of pharmacy, wanadongri,hingna road, Nagpur, Maharashtra. 441110
Surajit Saha
Bharat Pharmaceutical Technology, Amtali, Agartala, West Tripura. 799130
Neelmani Chauhan
Department of Pharmacy, Technocrates Institute of Technology, Bhopal, Madhya Pradesh. 462021
Nazia Malik
TRR College of Pharmacy, Pragathi Colony, Meerpet, Hyderabad, Telangana. 500097 Orcid : 0009-0008-8200-1993
Dighe Rajendra Dnyandeo
K.B.H.S.S. Trust's Institute of Pharmacy , Malegaon , Nashik (M.S)- 422009
Sumaiya Naaz
Azad College of Pharmacy, Moinabad, Ranga Reddy, Telangana. 500074 ORCID - 0009-0006-1787-7185
Seena KX
Department of Pharmacognosy, KMP College of Pharmacy, Perumbavoor, Ernakulam, Kerla, India. 683549
Sakshi Aole
School of Pharmacy, LNCTU, Near J K. Hospital, Kolar Road, Bhopal, Madhya Pradesh. 462041