EVALUATION OF ADAPTOGENIC POTENTIALS OF HYDROETHANOLIC EXTRACT OF GREWIA HIRSUTA VAHL. IN EXPERIMENTAL ANIMALS
Main Article Content
Keywords
Grewia hirsuta, adaptogenic, immobilization stress, anoxia stress tolerance, forced swimming endurance
Abstract
Objectives: To assess the adaptogenic activity of hydroethanolic extract of grewia hirsuta vahl. in experimentally induced stress.
Methods: Hydroethanolic extract of Grewia hirsuta (HEEGH) was tested at 250 and 500 mg/kg. The behavioral and biochemical studies comprises of glucose, cholesterol, triglycerides, total protein, SGPT, SGOT, BUN, and cortisol were estimated.
Results: Adrenocorticotropic hormone causes tropisms of adrenal glands and spleen at the expense of liver functions as a result of the stress induced response. The extract at two different level doses reduces the secretion of corticosterone from adrenal cortex and other biochemical (see table 1&5).
Conclusion: Grewia hirsuta Vahl. was used in folk & tribal medicine from the times immemorial fornervine, brain tonic, antipyretic, diuretic, carminative, aphrodisiac, cardiac tonic. The pharmacological activity of the extract was not as per the literature survey. Hence, our study which is known to reduce the cortisol secretion may be the cause for the stress.
References
2. Schneiderman N, Ironson G, Siegel SD. Stress and health psychological behavioral and biological determinants. Annu Rev Clin Psychol 2005;1:607-628.
3. O Connor DB, Thayer JF, Vedhara K. Stress and health a review of psychobiological processes. Annu Rev Psychol 2021;72:663-688.
4. Gupta A, Naraniwal M, Kothari V. Modern extraction methods for preparation of bioactive plant extracts. IJANS 2012;1(1):8-26.
5. Pawar VS, Shivakumar H. Screening methods for evaluation of adaptogenic agents a review.J Pharm Research2011;4(3):763-765.
6. Sudheer A, Sapkota HP, Dangi NB, Wagle N, Bindu RH, Sreedhar B. Evaluation of adaptogenic activity of methanolic extract of leaves of Tamarindus indica in rats and mice. IAJPR2015;5(06):2415-2424.
7. Singh S, Upadhyay A, Sirbaiya A. Neuropharmacological screening anti-stress activity and toxicity studies of standardized extract of the seeds of celastruspaniculatuswilld. Asian J Pharm Clin Res 2021;14(11):52-56.
8. Jahagirdar AQF, Hugar S, Patil VP, Khot A, Nanjappaiah HM. Screening of antistress activity of Ficus benghalensis fruit extract. Research J Pharm and Tech2020;13(1):191-196.
9. Darbar S, Saha S, Chattopadhyay S, Chattapadhyay A. Anti-stress activity (in-vivo) of multi herbal capsule-trasina® in experimental murine model. AJPRD2020;8(4):52 -58.
10. Kanase V, Shaikh S. Evaluation of antistress activity of ethanolic extract of chromolaena odorata leaves in albino wistar rats. Asian J Pharm Clin Res 2019; 12(11):50-55.
11. Jameel MK, Joshi AR, Dawane J, Padwal M, Joshi AR, Pandit VA. Effect of various physical stress models on serum cortisol level in wistar rats. J Clin Diagn Res 2014;8(3):181-183.
12. Ricart-Jane D, Rodriguez-Sureda V, Benavides A, Peinado-Onsurbe J, Lopez-Tejero MD, Llobera M. Immobilization stress alters intermediate metabolism and circulating lipoproteins in the rat. Metabolism 2002;51(7):925-31.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Vinuth Chikkamath
Research Scholar, PG Department of Pharmacology, SCS College of Pharmacy, Harapanahalli-583 131, Karnataka, India
Venkatrao. H. Kulkarni
Department of Pharmacology, SET’s College of Pharmacy, S R Nagar, Dharwad -580002,
Karnataka, India
Prasanna. V. Habbu
Department of Pharmacognosy, SET’s College of Pharmacy, S R Nagar, Dharwad - 580002, Karnataka, India.
Anantha Naik Nagappa
Department of Pharmacy, Himgiri Zee University, Dehradun, Uttarakhand, India.