EFFICACY OF 0.5% HYPERBARIC BUPIVACAINE VERSUS 0.75% ISOBARIC ROPIVACAINE FOR LOWER LIMB SURGERIES – A COMPARATIVE STUDY
Main Article Content
Keywords
.
Abstract
BACKGROUND: Ropivacaine, a recently introduced local anaesthetic, has approximately 40% reduced potency compared to bupivacaine. The objective of this study was to compare the clinical effectiveness of hyperbaric 0.75% ropivacaine and 0.5% bupivacaine for spinal anaesthesia during lower limb surgeries.
METHODOLOGY: A randomized double-blinded study was carried out in 60 participants who were divided into 2 groups. Group B were given 2ml intrathecal injection of 0.5% hyperbaric Bupivacaine kg while Group R were given an intrathecal dose of 2ml of 0.75% isobaric Ropivacaine. The variables like time taken for onset of sensory and motor block, duration of the blocks, time taken to reach T10 level were recorded.
RESULTS: Ropivacaine's slower time to motor blockade onset and shorter motor blockade duration compared to Bupivacaine were both highly significant with P value of 0.0001.
CONCLUSION: The utilisation of ropivacaine's recovery profile may prove advantageous in situations when immediate mobilisation is necessary.
References
2. Pollock JE, Neal JM, Stephenson CA, Wiley CE. Prospective study of the incidence of transient radicular irritation in patients undergoing spinal anesthesia. Anesthesiology 1996;84:1361-7.
3. Cpogna G, Cellono D, Fusco P, Lyons G, Columb M, relative potencies of bupivacaine and ropivacaine for analgesia in labor Br J Anaesth 1999; 82: 371.
4. Yamashita A, Matsumoto M, Matsumoto S, Itoh M, Kawai K, Sakabe T. A comparison of the neurotoxic effects on the spinal cord of tetracaine, lidocaine, bupivacaine, and ropivacaine administered intrathecally in rabbits. Anesth Analg 2003;97:512- 9.
5. Helena Kallio, Eljas-Veil T.Snall, Sami J.Suvanto, Carl A. Tuomas, Mauri K. Iivonen et al, Spinal hyperbaric ropivacaine fentanyl for day surgery, Regional anaesthesia and pain medicine, Jan/Feb 2005, volume 30, 48-54.
6. Jean-Marc Malinovsky, Florence Charles,Ottmar Kick, MD, Jean-Yves Lepage, Myriam Malinge, Antoine Cozian, MD, Olivier Bouchot, Michel Pinaud, Intrathecal Anesthesia: Ropivacaine Versus Bupivacaine Anesthesia and analgesia, December 2000 vol. 91 no. 6 1457-1460.
7. Luck JF, Fettes PD, Wildsmith JA. Spinal anaesthesia for elective surgery: A comparison of hyperbaric solutions of racemic bupivacaine, levobupivacaine, and ropivacaine. Br J Anaesth 2008;101:705-10.
8. Gautier C, de Kock M, Van Steenberge A, Poth N, Lahaye- Goffart B, Farnard L, Hody JL. Intrathecal ropivacaine for ambulatory surgery. A comparison between intrathecal ropivacaine for knee arthroscopy. Anesthesiology 1999;91:1239-1245.
9. Mantouvalou M, Ralli S, Arnaoutoglou H, Tziris G, Papadopoulos G. Spinal anesthesia: comparison of plain ropivacaine, bupivacaine and levobupivacaine for lower abdominal surgery. Acta Anaesthesiol Belg. 2008;59(2):65–71.
10. Kallio H, Snäll EVT, Tuomas CA, Rosenberg PH. Comparison of hyperbaric and plain ropivacaine 15 mg in spinal anaesthesia for lower limb surgery. British Journal of Anaesthesia. 2004 Nov;93(5):664–9.
11. McDonald SB, Liu SS, Kopacz DJ, Stephenson CA. Hyperbaric spinal ropivacaine: a comparison to bupivacaine in volunteers. Anesthesiology 1999; 90: 971-7.