Zinc Oxide Conjugated Rutin Trihydrate Nanocomposite For Application In Dry Socket

Main Article Content

S.Varshasree
Sandhya Sundar
Saranya Kannan
Ramya Ramadoss
Suganya Paneerselvam
Pratibha Ramani

Keywords

Alveolar osteitis,zinc oxide,rutin trihydrate,gel formulation,healing ,antimicrobial effect

Abstract

Background: Dry socket or Alveolar osteitis is one of the most common and unpleasant post operative conditions after the extraction of permanent tooth.Zinc oxide is used for the treatment of dry socket and it is considered to be effective in relieving pain.Rutin trihydrate is also effectively used for antimicrobial activity.
Aim: To formulate and assess the physical, biological and healing properties of Zinc oxide and rutin trihydrate nanocomposites (ZnO-RTn).
Materials And Methods: Nutrient broth (1.3grams) is taken as a culture medium and dissolved in 100ml of water and is sterilized at 120℃. The bone slab is washed in saline and UV exposure is given for 30 minutes.Streptococcus mutans is added.Zinc oxide conjugated rutin trihydrate is added in another beaker and is incubated for 24 hours.SEM analysis is carried out.
Result: The nanoparticle was found to be in triangular shape which gives better surface interaction. The other elements present in the material source are carbon, oxygen, zinc.The cell viability was found to be 76.32%.
Conclusion: Due to the improvised properties of the nanoparticles ,they can find applications in the treatment modalities of various diseases.

Abstract 202 | pdf Downloads 85

References

1. Abdollahi, Yadollah. 2012. Zinc Oxide and Manganese Doped Zinc Oxide Nanoparticles: The Photodegradation of Cresols Under Visible-Light Irradiation by ZnO Nanoparticles. LAP Lambert Academic Publishing.
2. Alharbi, Rana A., Fahad M. Alminderej, Nouf F. Al-Harby, Noura Y. Elmehbad, and Nadia A. Mohamed. 2023. “Design, Synthesis, and Characterization of Novel Bis-Uracil ChitosanHydrogels Modified with Zinc Oxide Nanoparticles for Boosting Their Antimicrobial Activity.” Polymers 15 (4). https://doi.org/10.3390/polym15040980.
3. Alhoqail, Wardah A., Abdulaziz S. Alothaim, Mohd Suhail, Danish Iqbal, Mehnaz Kamal, Majid Mohammed Asmari, and Azfar Jamal. 2023. “Husk-like Zinc Oxide Nanoparticles Induce Apoptosis through ROS Generation in Epidermoid Carcinoma Cells: Effect of Incubation Period on Sol-Gel Synthesis and Anti-Cancerous Properties.” Biomedicines 11 (2). https://doi.org/10.3390/biomedicines11020320.
4. Almushalbn, Abdulsalam, Ahmad Albassal, and Munir Harfouch. 2022. “Comparative Clinical Study Between Chlorhexidine Gel (0.2%) and Hyaluronic Gel (1%) in the Prevention of a Dry Socket After Tooth Extraction for Orthodontic Treatment.” Cureus 14 (12): e32391.
5. Awasthi, Kamlendra. 2021. Nanostructured Zinc Oxide: Synthesis, Properties and Applications. Elsevier.
6. Awwad, Akl. 2013. Green Synthesis of Zinc Oxide Nanoparticles at Ambient Temperature. LAP Lambert Academic Publishing.
7. Babu, B. Vivek, B. Vivek Babu, Arvind Sivakumar, A. Sumathi Felicita, and Prasanna Arvind T. R. 2022. “Incidence Of Supernumerary Teeth In Uclp Patients Visiting Saveetha Dental College And Hospital.” Journal of Pharmaceutical Negative Results. https://doi.org/10.47750/pnr.2022.13.s06.347.
8. Chaudhari, Cinthura. 2020. “Maxillary Labial Frenum Morphology and Midline Diastema Among Children Aged 3-12 Years- A Cross-Sectional Study.” Bioscience Biotechnology Research Communications. https://doi.org/10.21786/bbrc/13.7/66.
9. Cheng, Jacquelyn, Nikolai Kolba, Alba García-Rodríguez, Cláudia N. H. Marques, Gretchen J. Mahler, and Elad Tako. 2023. “Food-Grade Metal Oxide Nanoparticles Exposure Alters Intestinal Microbial Populations, Brush Border Membrane Functionality and Morphology, In Vivo ().” Antioxidants (Basel, Switzerland) 12 (2). https://doi.org/10.3390/antiox12020431.
10. Costa, Renan R. da, Raquel D. S. Freitas, Gabriela da Cunha, Sílvia D. de Oliveira, and João B. B. Weber. 2023. “Antimicrobial and Bone Repair Effects of Boric Acid in a Rat Model of Dry Socket (alveolar Osteitis) Following Dental Extraction.” Journal of Trace Elements in Medicine and Biology: Organ of the Society for Minerals and Trace Elements 76 (March): 127118.
11. Daly, Blánaid Jm, Mohammad O. Sharif, Kate Jones, Helen V. Worthington, and Anna Beattie. 2022. “Local Interventions for the Management of Alveolar Osteitis (dry Socket).” Cochrane Database of Systematic Reviews 9 (9):
CD006968.
12. Deng, Xuyang, Danyang Wang, Dongjie Zhang, Ming Sun, Liying Zhou, Yuxi Wang, Xiaowen Kong, Changqing Yuan, and Qihui Zhou. 2022. “Antibacterial Quaternary Ammonium Chitosan/carboxymethyl Starch/alginate Sponges with Enhanced Hemostatic Property for the Prevention of Dry Socket.” Frontiers in Bioengineering and Biotechnology 10: 1083763.
13. Galvan, Carmen. 2020. Zinc Oxide: Production, Properties and Applications.
14. Health Central. 2019. Reversing Dry Socket: Overcoming Cravings the Raw Vegan Plant-Based Detoxification & Regeneration Workbook for Healing Patients. Raw Power.
15. Lin, Gang, Xiaoliang Zhou, Limin Liu, Huangmin Li, Di Huang, Jing Liu, Jie Li, and Zhaohuan Wei. 2023. “Performance Improvement of Aqueous Zinc Batteries by Zinc Oxide and Ketjen Black Co-Modified Glass Fiber Separators.” RSC Advances 13 (10): 6453–58.
16. Merchant, Aman, Subhabrata Maiti, Vaishnavi Rajaraman, Ashok Velayudhan, and Dhanraj M. Ganapathy. 2022. “Comparative Analysis of Pink and White Esthetics of Anterior Full Veneer Crown: Indian Scenario.” Journal of Advanced Pharmaceutical Technology & Research 13 (Suppl 1): S282–87.
17. Mouriaux, Frederic. 2022. “How to Analyze Conjunctival Inflammation in Dry Anophthalmic Socket Syndrome (DASS)?” Graefe’s Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, November. https://doi.org/10.1007/s00417-022-05899-w.
18. Nahhas, Dr Ahmed. 2019. Zinc Oxide Based Nano Materials and Devices. BoD – Books on Demand.
19. Quercus Corporation. 1976. Assisting with Suture Placement, Removing Sutures and Treatment of Dry Sockets.
20. Rokohl, Alexander C., Katharina Wall, Marc Trester, Philomena A. Wawer Matos, Yongwei Guo, Werner Adler, Keith R. Pine, and Ludwig M. Heindl. 2022. “Novel Point-of-Care Biomarkers of the Dry Anophthalmic Socket Syndrome: Tear Film Osmolarity and Matrix Metalloproteinase 9 Immunoassay.” Graefe’s Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, November. https://doi.org/10.1007/s00417-022-05895-0.
21. Sathish, Thanikodi, Abdul Razak R. Kaladgi, V. Mohanavel, K. Arul, Asif Afzal, Abdul Aabid, Muneer Baig, and Bahaa Saleh. 2021. “Experimental Investigation of the Friction Stir Weldability of AA8006 with Zirconia Particle Reinforcement and Optimized Process Parameters.” Materials 14 (11).https://doi.org/10.3390/ma14112782.
22. Sivarajan, Madhumithaa, A. S. Smiline Girija, A. Paramasivam, and J. Vijayashree Priyadharsini. 2020. “Computational Approach to Identify Mutations in Genes of Notch Signaling Pathway and Its Association with OSCC.” Journal of Pharmaceutical Research International. https://doi.org/10.9734/jpri/2020/v32i2030732.
23. Subramaniam, Nandhini, and Arvind Muthukrishnan. 2021. “Management of Patients under Bone Anti-Resorptive Drugs- A Survey among Dental Practitioners.” Research Journal of Pharmacy and Technology. https://doi.org/10.52711/0974-360x.2021.00871.
24. Sun, Yu-Qi, Rui Sun, and Ji-Hong Zhao. 2022. “The Efficacy of Minocycline Hydrochloride Ointment versus Iodoform Gauze for Alveolar Osteitis: A Prospective Cohort Study.” BMC Oral Health 22 (1): 448.
25. Thamizhanambi, Tamizh Paavai, Annasamy Rameshkumar, Ramadoss Ramya, Rajkumar Krishnan, Thayalan Dineshkumar, and Gunasekaran Nandhini. 2022. “Analysis of Metabolic Regulators PGC1-α and PGC1-β in Oral Squamous Cell Carcinoma with and without Hyperglycemia.” Asian Pacific Journal of Cancer Prevention: APJCP 23 (8): 2797–2803.
26. Thorat, Sagar D., and Kumar Nilesh. 2022. “Efficacy of Low-Level Laser Therapy in the Management of Postoperative Surgical Sequelae after Surgical Removal of Impacted Mandibular Third Molars.” National Journal of Maxillofacial Surgery 13 (Suppl 1): S52–56.
27. Yan, Yupeng, Xionghan Feng, Xiaoming Wang, Wei Li, Shuai Lan, Lirong Zheng, Qin Zhang, and Biao Wan. 2023. “Transformation of Zinc Oxide Nanoparticles in the Presence of Aluminum Oxide with Pre-Sorbed Phosphorus Ligands.” Environment International 173 (February): 107847.
28. Abdollahi, Yadollah. 2012. Zinc Oxide and Manganese Doped Zinc Oxide Nanoparticles: The Photodegradation of Cresols Under Visible-Light Irradiation by ZnO Nanoparticles. LAP Lambert Academic Publishing.
29. Alharbi, Rana A., Fahad M. Alminderej, Nouf F. Al-Harby, Noura Y. Elmehbad, and Nadia A. Mohamed. 2023. “Design, Synthesis, and Characterization of Novel Bis-Uracil Chitosan Hydrogels Modified with Zinc Oxide Nanoparticles for Boosting Their Antimicrobial Activity.” Polymers 15 (4). https://doi.org/10.3390/polym15040980.
30. Alhoqail, Wardah A., Abdulaziz S. Alothaim, Mohd Suhail, Danish Iqbal, Mehnaz Kamal, Majid Mohammed Asmari, and Azfar Jamal. 2023. “Husk-like Zinc Oxide Nanoparticles Induce Apoptosis through ROS Generation in Epidermoid Carcinoma Cells: Effect of Incubation Period on Sol-Gel Synthesis and Anti-
Cancerous Properties.” Biomedicines 11 (2). https://doi.org/10.3390/biomedicines11020320.
31. Almushalbn, Abdulsalam, Ahmad Albassal, and Munir Harfouch. 2022. “Comparative Clinical Study Between Chlorhexidine Gel (0.2%) and Hyaluronic Gel (1%) in the Prevention of a Dry Socket After Tooth Extraction for Orthodontic Treatment.” Cureus 14 (12): e32391.
32. Awasthi, Kamlendra. 2021. Nanostructured Zinc Oxide: Synthesis, Properties and Applications. Elsevier.
33. Awwad, Akl. 2013. Green Synthesis of Zinc Oxide Nanoparticles at Ambient Temperature. LAP Lambert Academic Publishing.
34. Chaudhari, Cinthura. 2020. “Maxillary Labial Frenum Morphology and Midline Diastema Among Children Aged 3-12 Years- A Cross-Sectional Study.” Bioscience Biotechnology Research Communications. https://doi.org/10.21786/bbrc/13.7/66.
35. Cheng, Jacquelyn, Nikolai Kolba, Alba García-Rodríguez, Cláudia N. H. Marques, Gretchen J. Mahler, and Elad Tako. 2023. “Food-Grade Metal Oxide Nanoparticles Exposure Alters Intestinal Microbial Populations, Brush Border Membrane Functionality and Morphology, In Vivo ().” Antioxidants (Basel, Switzerland) 12 (2). https://doi.org/10.3390/antiox12020431.
36. Costa, Renan R. da, Raquel D. S. Freitas, Gabriela da Cunha, Sílvia D. de Oliveira, and João B. B. Weber. 2023. “Antimicrobial and Bone Repair Effects of Boric Acid in a Rat Model of Dry Socket (alveolar Osteitis) Following Dental Extraction.” Journal of Trace Elements in Medicine and Biology: Organ of the Society for Minerals and Trace Elements 76 (March): 127118.
37. Daly, Blánaid Jm, Mohammad O. Sharif, Kate Jones, Helen V. Worthington, and Anna Beattie. 2022. “Local Interventions for the Management of Alveolar Osteitis (dry Socket).” Cochrane Database of Systematic Reviews 9 (9): CD006968.
38. Deng, Xuyang, Danyang Wang, Dongjie Zhang, Ming Sun, Liying Zhou, Yuxi Wang, Xiaowen Kong, Changqing Yuan, and Qihui Zhou. 2022. “Antibacterial Quaternary Ammonium Chitosan/carboxymethyl Starch/alginate Sponges with Enhanced Hemostatic Property for the Prevention of Dry Socket.” Frontiers in Bioengineering and Biotechnology 10: 1083763.
39. Galvan, Carmen. 2020. Zinc Oxide: Production, Properties and Applications.
40. Health Central. 2019. Reversing Dry Socket: Overcoming Cravings the Raw Vegan Plant-Based Detoxification & Regeneration Workbook for Healing Patients. Raw Power.
41. Lin, Gang, Xiaoliang Zhou, Limin Liu, Huangmin Li, Di Huang, Jing Liu, Jie Li, and Zhaohuan Wei. 2023. “PerformanceImprovement of Aqueous Zinc Batteries by Zinc Oxide and Ketjen Black Co-Modified Glass Fiber Separators.” RSC Advances 13 (10): 6453–58.
42. Merchant, Aman, Subhabrata Maiti, Vaishnavi Rajaraman, Ashok Velayudhan, and Dhanraj M. Ganapathy. 2022. “Comparative Analysis of Pink and White Esthetics of Anterior Full Veneer Crown: Indian Scenario.” Journal of Advanced Pharmaceutical Technology & Research 13 (Suppl 1): S282–87.
43. Mouriaux, Frederic. 2022. “How to Analyze Conjunctival Inflammation in Dry Anophthalmic Socket Syndrome (DASS)?” Graefe’s Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, November. https://doi.org/10.1007/s00417-022-05899-w.
44. Nahhas, Dr Ahmed. 2019. Zinc Oxide Based Nano Materials and Devices. BoD – Books on Demand.
45. Quercus Corporation. 1976. Assisting with Suture Placement, Removing Sutures and Treatment of Dry Sockets.
46. Rokohl, Alexander C., Katharina Wall, Marc Trester, Philomena A. Wawer Matos, Yongwei Guo, Werner Adler, Keith R. Pine, and Ludwig M. Heindl. 2022. “Novel Point-of-Care Biomarkers of the Dry Anophthalmic Socket Syndrome: Tear Film Osmolarity and Matrix Metalloproteinase 9 Immunoassay.” Graefe’s Archive for Clinical and Experimental
Ophthalmology = Albrecht von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, November. https://doi.org/10.1007/s00417-022-05895-0.
47. Sun, Yu-Qi, Rui Sun, and Ji-Hong Zhao. 2022. “The Efficacy of Minocycline Hydrochloride Ointment versus Iodoform Gauze for Alveolar Osteitis: A Prospective Cohort Study.” BMC Oral Health 22 (1): 448.
48. Thamizhanambi, Tamizh Paavai, Annasamy Rameshkumar, Ramadoss Ramya, Rajkumar Krishnan, Thayalan Dineshkumar, and Gunasekaran Nandhini. 2022. “Analysis of Metabolic Regulators PGC1-α and PGC1-β in Oral Squamous Cell Carcinoma with and without Hyperglycemia.” Asian Pacific Journal of Cancer Prevention: APJCP 23 (8): 2797–2803.
49. Thorat, Sagar D., and Kumar Nilesh. 2022. “Efficacy of Low-Level Laser Therapy in the Management of Postoperative Surgical Sequelae after Surgical Removal of Impacted Mandibular Third Molars.” National Journal of Maxillofacial Surgery 13 (Suppl 1): S52–56.
50. Yan, Yupeng, Xionghan Feng, Xiaoming Wang, Wei Li, Shuai Lan, Lirong Zheng, Qin Zhang, and Biao Wan. 2023. “Transformation of Zinc Oxide Nanoparticles in the Presence of Aluminum Oxide with Pre-Sorbed Phosphorus Ligands.” Environment International 173 (February): 107847.

Most read articles by the same author(s)

1 2 3 > >>