A Review Of Innovations And Advances In The Management Of Oral Squamous Cell Carcinoma In Improving Quality Of Life
Main Article Content
Keywords
head and neck cancers, multimodal treatment, biomarkers, robotic surgeries
Abstract
Squamous cell carcinoma of the oral cavity is the sixth most common malignancy worldwide. A skilled multidisciplinary team is required for effective management and the best results. The contemporary practice of managing oral squamous cell carcinoma often requires a multimodal approach of surgery and chemoradiation. But despite this aggressive multimodal treatment, 40% to 60% of the patients will have a relapse. This paper briefly outlines the recent advances and innovations in diagnosis, management strategy, and prognostic aspects of head and neck squamous cell carcinoma. The most crucial objective of a biomarker in cancer is the accurate detection of the tiniest amount of tumor cells prior to growth, when the patient's clinical prognosis and outcome are still favorable.
References
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2. Adjogatse D, Petkar I, Reis Ferreira M, Kong A, Lei M, Thomas C, et al. The Impact of Interactive MRI-Based Radiologist Review on Radiotherapy Target Volume Delineation in Head and Neck Cancer. AJNR Am J Neuroradiol. 2023 Feb;44(2):192–8.
3. Su YF, Chen YJ, Tsai FT, Li WC, Hsu ML, Wang DH, et al. Current Insights into OralCancer Diagnostics. Diagnostics [Internet]. 2021 Jul [cited 2023 Feb 27];11(7). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8303371/
4. McCullough MJ, Farah CS. The assessment of the DNA content of oral cytology via virtual microscopy for the early detection of epithelial dysplasia and neoplasia in oral mucosal lesions [Internet]. Vol. 45, Oral Oncology. 2009. p. e114–5. Available from: http://dx.doi.org/10.1016/j.oraloncology.2009.06.009
5. Afrogheh A, Pelser A, Attwood R, Schubert P, Hille J. Application of Liquid-Based Trans-Epithelial Flexible Brush Cytology in Detection of High-Grade Laryngeal Mucosal Lesions [Internet]. Vol. 119, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2015. p. e202. Available from: http://dx.doi.org/10.1016/j.oooo.2014.07.443
6. 王映. Significance of VEL scope Fluorescence System in Assisting Diagnosis of Different Types of Oral Lichen Planus [Internet]. Vol. 11, Advances in Clinical Medicine. 2021. p. 4206–11. Available from: http://dx.doi.org/10.12677/acm.2021.119614
7. K Chaitanya NCS, Chavva S, Surekha E, Priyanka V, Akhila M, Ponnuru HK, et al. A Meta-analysis on efficacy of auto fluorescence in detecting the early dysplastic changes of oral cavity. South Asian J Cancer. 2019 Oct-Dec;8(4):233–6.
8. Sambandham T, Masthan KMK, Kumar MS, Jha A. The application of vizilite in oral cancer. J Clin Diagn Res. 2013 Jan;7(1):185–6.
9. Ramdoss R, Yuwanati M, Viola E A, Ramani P, Murugan MS. Can koilocytes without dysplasia in OPMDs be an early indicator and prognostic factor for oral squamous cell carcinoma? Oral Oncol. 2022 Jan;124:105672.
10. Schwarz RA, Richards-Kortum RR, Gillenwater AM. Fluorescence and Reflectance Spectroscopy for Detection of Oral Dysplasia and Cancer [Internet]. Biomedical Optics in Otorhinolaryngology. 2016. p. 431–49. Available from: http://dx.doi.org/10.1007/978-1-4939-1758-7_26
11. Sarode GS, Sarode SC, Yuwanati M, Gadbail A, Gondivkar S. Lichenoid infiltrate in oral submucous fibrosis: A new marker of malignant transformation. Oral Oncol. 2022 Jan;124:105671.
12. Ramadoss R, Yuwanati M, Ramani P, Krishnan R, Annasamy R. Glandular metaplasia in oral squamous cell carcinoma: Prognostic indicators? Deriving inference from urothelial and breast carcinoma. Oral Oncol. 2022 Jan;124:105639.
13. Kuriakose MA. Contemporary Oral Oncology: Biology, Epidemiology, Etiology, and Prevention. Springer; 2016. 541 p.
14. Renu K, Veeraraghavan VP, Raj A T, Patil S, Valsala Gopalakrishnan A. The peroxisome proliferator-activated receptor-alpha (PPAR-α): A new therapeutic target for oral cancer. Oral Oncol. 2022 Sep;132:106007.
15. Kumaresan V, Sivaperumal P, Smiline Girija AS. Bispecific antibodies targeting tumor-associated metalloprotease and recruit NK cells - Multifunctional therapeutic approach against oral cancer. Oral Oncol. 2022 Sep;132:106013.
16. Lu W, Wang Y, Gan M, Duan Q. Prognosis and predictive value of heat-shock proteins expression in oral cancer: A PRISMA-compliant meta-analysis. Medicine . 2021 Jan 22;100(3):e24274.
17. Balachander K, Paramasivam A. Anti-PD-1 agent: A promising immunotherapy drug for oral cancer? Oral Oncol. 2022 Sep;132:105997.
18. Shree Harini K, Ezhilarasan D, Lakshmi T. Novel fibroblast growth factor receptor inhibitors: Potential therapeutic approach in oral cancer treatment. Oral Oncol. 2022 Sep;132:105983.
19. Revathi D, Dhanraj G, Ashok V. Immune check point inhibitors: A promising therapeutic approach in oral cancer. Oral Oncol. 2022 Sep;132:105977.
20. Ramadoss R, Sundar S, Panneer Selvam S, Trivandrum Anandapadmanabhan L. Delineating atypia and dysplasia - Addressing the grey zone. Oral Oncol. 2022 Nov;134:106091.
21. Pazhani J, Veeraraghavan VP, Jayaraman S. Aurora kinase in oral cancer: A potential therapeutic target to improve treatment efficiency. Oral Oncol. 2022 Nov;134:106093.
22. Elumalai P, Ezhilarasan D. Emerging applications of CRISPR/Cas9 gene editing technology in reversing drug resistance in oral squamous cell carcinoma. Oral Oncol. 2022 Nov;134:106100.
23. Nordemar S. Molecular Markers in Head and Neck Cancers [Internet]. Otorhinolaryngology: Head and Neck Surgery (2 Volumes). 2017. p. 158–158. Available from: http://dx.doi.org/10.5005/jp/books/13036_13
24. Prasad M, Jayaraman S, Rajagopal P, Veeraraghavan VP. Apoptosis regulating CircRNAs: Emerging role in oral cancer therapeutics. Oral Oncol. 2022 Nov;134:106107.
25. Shree Harini K, Ezhilarasan D, Elumalai P. Restoring the anti-tumor property of PTEN: A promising oral cancer treatment. Oral Oncol. 2022 Nov;134:106113.
26. Eze N, Lo YC, Burtness B. Biomarker driventreatment of head and neck squamous cell cancer [Internet]. Vol. 2, Cancers of the Head & Neck. 2017. Available from: http://dx.doi.org/10.1186/s41199-017-0025-1
27. Yuwanati M, Sarode SC, Sarode GS, Gadbail A, Gondivkar S. Telomerase reverse transcriptase mutation: A risk predictor and drug target for oral squamous cell carcinoma and its precursors. Oral Oncol. 2022 Nov;134:106120.
28. Cheng YSL, Jordan L, Rees T, Chen HS, Oxford L, Brinkmann O, et al. Erratum to: Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients [Internet]. Vol. 18, Clinical Oral Investigations. 2014. p. 995–995. Available from: http://dx.doi.org/10.1007/s00784-013-1127-8
29. Manjusha M, Saravanan M. Oropharyngeal cancer associated with sarcopenic obesity and sarcopenic weight loss. Oral Oncol. 2022 Nov;134:106101.
30. Wang L, Li. Y. Predictive Fuzzy Neural Network Based Effect of Heat Shock Protein on Prognosis of Tumor Cells [Internet]. Vol. 10, Journal of Medical Imaging and Health Informatics. 2020. p. 2037–41. Available from: http://dx.doi.org/10.1166/jmihi.2020.3132
31. O??Malley BW, Weinstein GS, Snyder W, Hockstein NG. Transoral Robotic Surgery (TORS) for Base of Tongue Neoplasms [Internet]. Vol. 116, The Laryngoscope. 2006. p. 1465–72. Available from: http://dx.doi.org/10.1097/01.mlg.0000227184.90514.1a
32. Weinstein GS, O’Malley BW, Snyder W, Sherman E, Quon H. Transoral Robotic Surgery [Internet]. Vol. 133, Archives of Otolaryngology–Head & Neck Surgery. 2007. p. 1220. Available from: http://dx.doi.org/10.1001/archotol.133.12.1220
33. Brunet-Garcia A, Faulkner J, Jeannon JP, Rovira A, Simo R, Arora A. P-166 Guy’s Institutional experience in Transoral Robotic Surgery for oropharyngeal squamous cell carcinoma [Internet]. Vol. 118, Oral Oncology. 2021. p. 19. Available from: http://dx.doi.org/10.1016/s1368-8375(21)00452-8
34. Jain S, Raza K, Agrawal AK, Vaidya A. Nanotechnology Applications for Cancer Chemotherapy. Elsevier; 2020. 702 p.
35. Beg S, Rahman M, Choudhry H, Souto EB, Ahmad FJ. Nanoformulation Strategies for Cancer Treatment. Elsevier; 2020. 402 p.
36. Satapathy S, Patro CS. Solid Lipid Nanoparticles for Efficient Oral Delivery of Tyrosine Kinase Inhibitors: A Nano Targeted Cancer Drug Delivery. Adv Pharm Bull. 2022 Mar;12(2):298–308.
37. Gorantla S, Wadhwa G, Jain S, Sankar S, Nuwal K, Mahmood A, et al. Recent advances in nanocarriers for nutrient delivery. Drug Deliv Transl Res. 2022 Oct;12(10):2359–84.
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Jun 24, 2023
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Raparthy Bhuvana chandra, Kathiravan Selvarasu, Murugesan K, Manoj Kumar V, & Santhosh Kumar. (2023). A Review Of Innovations And Advances In The Management Of Oral Squamous Cell Carcinoma In Improving Quality Of Life. Journal of Population Therapeutics and Clinical Pharmacology, 30(16), 195-200. https://doi.org/10.47750/jptcp.2023.30.16.025
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All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Raparthy Bhuvana chandra, Kathiravan Selvarasu, Murugesan K, Manoj Kumar V, & Santhosh Kumar. (2023). A Review Of Innovations And Advances In The Management Of Oral Squamous Cell Carcinoma In Improving Quality Of Life. Journal of Population Therapeutics and Clinical Pharmacology, 30(16), 195-200. https://doi.org/10.47750/jptcp.2023.30.16.025