Synthesis characterization and Preliminary Pharmacological Evaluation of new 2-pyrazoline derivatives derived from resorcinol
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Keywords
Pharmacological, derivatives, Synthesis, antioxidant
Abstract
Chalcones were used to create a number of 2-pyrazoline derivatives, which were then tested for their pharmacological effects.
Claisen-Schmidt prepared the chalcones (1–5). Acetophenone was used as the condensing agent in a reaction with several para-substituted benzaldehydes while KOH was present. The reaction was monitored by TLC, and the resultant intermediates were examined by melting point and FT-IR.
Various In a single pot, chalcones (1–5) and Hydrazine monohydrate were reacted with glacial acetic acid at a temperature of 50 °C for roughly 24 hours to produce 2-pyrazoline derivatives. The antioxidant chemical (guaiacol) was added after pyrazoline II (1–5) was produced, and the reaction was then watched by TLC to make sure it was finished. The mixture was chilled until crystal formation was complete in an ice-water bath. the 2-pyrazoline derivatives a1, b1, c1, d1, and e1 by adding them to crushed ice, storing them in the refrigerator for the next day, filtering, recrystallizing, and drying them. Based on their spectral data, the structures of the recently synthesized 2-pyrazoline derivatives have been established. The synthetic compounds were tested for their anti-inflammatory and antibacterial properties.
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