Role of Autologous Platelet Rich Plasma in Management of Chronic Wounds
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Keywords
Chronic wounds, Plasma rich platelet, Non-healing wounds
Abstract
Background and Aim: Globally, the incidence of chronic wounds rose (1.9% to 13.1%) with age, with an estimated 10% of the population developing chronic wounds, resulting in a 2.5% mortality rate. The purpose of the present study was to assess the role of autologous platelet rich plasma (PRP) in management of chronic wounds.
Materials and Methods: A randomized control trial was conducted on 46 chronic wounds patients in General Surgery Unit of Mardan Medical Complex, Mardan Pakistan from 6th August 2022 to 5th February 2023. All the chronic wounds patients with traumatic wounds and diabetes were enrolled. PRP was used as a saturated dressing "non-absorbable dressing with paraffin gauze" or as a local injection in the wound margins. Reduction in the size of ulcers in terms of volume and area was assessed after first, second, third, and fourth week.
Results: The overall mean age was 42.8 ± 4.6 years. There were 32 (69.6%) male and 12 (30.4%) females. The incidence of diabetes wounds, venous ulcers wounds, and traumatic wound was 82.6% (n=38), 13% (n=6), and 4.4% (n=2) respectively. The pre-treatment and after 6th injection session area of wound was 4.4±5.7 and 1±2.2 respectively revealing the 77.8% reduction in wound area that is considered as statistically significant (P-value <0.001).
Conclusion: The different etiologies of chronic wounds can be effectively managed by PRP. Additionally, PRP is a safe, economical, biocompatible, and straightforward treatment for chronic or non-healing wounds.
References
2. Montaser LM, Eid TA, Helwa MA, Mesregah MK. Application of platelet‑rich plasma preparation rich in growth factors in knee osteoarthritis. Menoufa Med J 2017; 30:139–146.
3. Farahat A, Salah H, Al‑Shraim M. Evaluation of the clinical and histopathological effect of platelet rich plasma on chronic wound healing. Int Res J Basic Clin Stud 2014; 2:55–61.
4. Conde Montero E, Fernández Santos ME, Suárez Fernández R. Platelet‑rich plasma: applications in dermatology. Actas Dermosifliogr 2015; 106:104–111.
5. Lynch MD, Bashir S. Applications of platelet rich plasma in dermatology: a critical apprais‑ al of the literature. J Dermatolog Treat 2016; 27:285–289.
6. Smith OJ, Kanapathy M, Khajuria A, Prokopenko M, Mann H, Mosahebi A, et al. Protocol for a systematic review of the effcacy of fat grafting and platelet‑rich plasma for wound healing, Syst Rev 2017; 6:111.
7. Conde‑Montero E, de la Cueva Dobao P, Martínez González JM. Platelet‑rich plasma for
the treatment of chronic wounds: evidence to date. Chronic Wound Care Manage Res 2017; 2017:107–120.
8. Cobos R, Aizpuru F, Parraza N, Anitua E, Orive G. Effectiveness and effciency of platelet rich plasma in the treatment of diabetic ulcers. Curr Pharm Biotechnol 2015; 16:630–634.
9. Kapp, S.; Miller, C.; Santamaria, N. The quality of life of people who have chronic wounds and who self-treat. J. Clin. Nurs. 2018, 27, 182–192.
10. Olsson, M.; Järbrink, K.; Divakar, U.; Bajpai, R.; Upton, Z.; Schmidtchen, A.; Car, J. The humanistic and economic burden of chronic wounds: A systematic review. Wound Repair Regen. 2019, 27, 114–125.
11. Morton, L.M.; Phillips, T.J. Wound healing and treating wounds: Differential diagnosis and evaluation of chronic wounds. J. Am. Acad. Derm. 2016, 74, 589–605, quiz 5–6.
12. Powers, J.G.; Higham, C.; Broussard, K.; Phillips, T.J. Wound healing and treating wounds: Chronic wound care and management. J. Am. Acad. Derm. 2016, 74, 607–625, quiz 25–26.
13. Hesseler, M.J.; Shyam, N. Platelet-rich plasma and its utility in medical dermatology: A systematic review. J. Am. Acad. Derm. 2019, 81, 834–846.
14. Qu, W.; Wang, Z.; Hunt, C.; Morrow, A.S.; Urtecho, M.; Amin, M.; Shah, S.; Hasan, B.; Abd-Rabu, R.; Ashmore, Z.; et al. The effectiveness and safety of platelet-rich plasma for chronic wounds: A systematic review and meta-analysis. Mayo Clin. Proc. 2021, 96, 2407–2417.
15. Abd El-Mabood, E.A.; Ali, H.E. Platelet-rich plasma versus conventional dressing: Does this really affect diabetic foot woundhealing outcomes? Egypt. J. Surg. 2018, 37, 16–26.
16. Ahmed, M.; Reffat, S.A.; Hassan, A.; Eskander, F. Platelet-rich plasma for the treatment of clean diabetic foot ulcers. Ann. Vasc. Surg. 2017, 38, 206–211.
17. Alamdari, N.M.; Sha, A.; Mirmohseni, A.; Besharat, S. Evaluation of the efficacy of platelet-rich plasma on healing of clean diabetic foot ulcers: A randomized clinical trial in Tehran, Iran. Diabetes Metab. Syndr. Clin. Res. Rev. 2021, 15, 621–626.
18. Amato, B.; Farina, M.A.; Campisi, S.; Ciliberti, M.; di Donna, V.; Florio, A.; Grasso, A.; Miranda, R.; Pompeo, F.; Farina, E.; et al. Cgf treatment of leg ulcers: A randomized controlled trial. Open Med. 2020, 14, 959–967.
19. Burgos-Alonso, N.; Lobato, I.; Hernandez, I.; Sebastian, K.S.; Rodriguez, B.; March, A.G.; Perez-Salvador, A.; Arce, V.; GarciaAlvarez, A.; Gomez-Fernandez, M.C.; et al. Autologous platelet-rich plasma in the treatment of venous leg ulcers in primary care: A randomized controlled, pilot study. J. Wound Care 2018, 27, S20–S24.
20. Cardenosa, M.E.; Dominguez-Maldonado, G.; Cordoba-Fernandez, A. Efficacy and safety of the use of platelet-rich plasma to manage venous ulcers. J. Tissue Viability 2017, 26, 138–143.
21. Chandanwale, K.A.; Mahakalkar, C.C.; Kothule, A.K.; Khithani, D.V. Management of wounds of peripheral arterial disease using platelet rich plasma. J. Evol. Med. Dent. Sci. 2020, 9, 2239–2245.
22. de Oliveira, M.G.; Abbade, L.P.F.; Miot, H.A.; Ferreira, R.R.; Deffune, E. Pilot study of homologous platelet gel in venous ulcers. An. Bras. Dermatol. 2017, 92, 499–504.
23. Goda, A.A. Autogenous leucocyte-rich and platelet-rich fibrin for the treatment of leg venous
ulcer: A randomized control study. Egypt. J. Surg. 2018, 37, 316–321.
24. Gude, W.; Hagan, D.; Abood, F.; Clausen, P. Aurix gel is an effective intervention for chronic diabetic foot ulcers: A pragmatic randomized controlled trial. Adv. Ski. Wound Care 2019, 32, 416–426.
25. Helmy, Y.; Farouk, N.; Dahy, A.A.; Abu-Elsoud, A.; Khattab, R.F.; Mohammed, S.E.; Gad, L.A.; Altramsy, A.; Hussein, E.; Farahat, A. Objective assessment of platelet-rich plasma (prp) potentiality in the treatment of chronic leg ulcer: Rct on 80 patients with venous ulcer. J. Cosmet. Dermatol. 2021, 20, 3257–3263.
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