Enhancement of silymarin solubility and dissolution by nicotinamide-based solid dispersion employing the kneading method
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Keywords
pharmaceutical; silymarin solubility; nicotinamide-based
Abstract
Silymarin (SM) is a herbal medicine extracted from the plant Silybum marianum. SM has many potent pharmacological activities among which are antioxidant, anti-inflammatory, and possible wound-healing properties. It belongs to BCS class II thus the drug is practically water insoluble with poor dissolution. In this paper the main aim is to modify solubility and dissolution of SM , one SD preparation method is used which is the Kneading method (Kn). The carrier that has being used is nicotinamide(NA) , Nicotinamide shows promise for the treatment of a wide range of dermatological conditions including autoimmune blistering disorders, acne, rosacea, ageing skin and atopic dermatitis. In particular, recent studies have also shown it to be a potential agent for wound healing, reducing actinic keratoses and preventing skin cancers. Solid dispersion (SD) was characterized for percentage yield, drug content, saturation solubility, and in-vitro dissolution study in comparing to pure drug. Formulation evaluated by Fourier-transform infrared spectroscopy, differential scanning colorimetry, X-ray diffraction.
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