Association of Serum Gelsolin with Thyroid Dysfunction in Hypothyroidism Patients : A case-control study
Main Article Content
Keywords
Gelsolin, hypothyroidism, overt hypothyroidism, subclinical hypothyroidism, insulin resistance
Abstract
Background: The thyroid hormone, also known as TH, plays a role in a wide variety of metabolic processes, including the promotion of the oxidation of carbohydrates, lipids, and proteins in a variety of tissues. There is a correlation between thyroid dysfunction and metabolic disorders. Gelsolin) GSN) a protein that under the control of Ca2+ sever, caps, and nucleates actin filaments, is a universal, a regulator of multiple cellular processes, including structure and metabolism.
Aims: The purpose of this investigation was to analyze the different levels of gelsolin in patients' serum hypothyroidism has correlate with insulin resistance and thyroid hormones as potential predictor marker for prognosis and complications in this group of patients.
Materials and Methods: A case-control investigation was carried out with a sample size of 120 patients and a control group (HC) of 60 individuals aged 20-50. Two groups of sixty patients, those with overt hypothyroidism (OH) and those with subclinical hypothyroidism (SCH), were created. Enzyme-linked immunosorbent assays (ELISAs) were used to measure serum levels of GSN, FIN, TT3, TT4, and TSH. Methods involving enzymes and colorimetry were used to quantify lipid profiles.
Results: Serum levels of GSN were decrease in hypothyroidism patient groups. However, as compared to the subclinical patients, significantly higher levels of GSN were reduced in overt groups. Overt hypothyroidism Patients (0.08 ± 0.04) had significantly lower serum GSN levels than subclinical hypothyroidism patients (0.13 ± 0.03). While, Healthy control group (0.17 ± 0.03), (P 0.001). This factor appears to be a significant predictor of hypothyroid-related complications. In the OH group, serum GSN levels correlated negatively with both age and TT3 concentrations. whereas a significantly negativity correlated with TT3 and TG levels in SCH group.
Conclusion: in this study concluded, serum GSN concentration was lower in hypothyroidism patients especially in OH group compared to the SCH group and HC group. Serum GSN, a naturally abundant circulating protein, is quickly depleted and consumed after extensive tissue injury, which may explain the decline in GSN levels. Thyroid and other organ damage can be avoided if people realize that severe depletion is associated with poor outcomes in a wide range of clinical situations involving severe inflammatory diseases.
References
2. Shi, X., et al., Optimal and safe upper limits of iodine intake for early pregnancy in iodine-sufficient regions: a cross-sectional study of 7190 pregnant women in China. 2015. 100(4): p. 1630-1638.
3. Han, C., et al., High body mass index is an indicator of maternal hypothyroidism, hypothyroxinemia, and thyroid-peroxidase antibody positivity during early pregnancy. 2015. 2015.
4. Duntas, L.H. and B.J.T. Biondi, The interconnections between obesity, thyroid function, and autoimmunity: the multifold role of leptin. 2013. 23(6): p. 646-653.
5. Zou, S., et al., Iodine nutrition and the prevalence of thyroid disease after salt iodization: a cross-sectional survey in Shanghai, a coastal area in China. 2012.
6. Iwen, K.A., E. Schröder, and G.J.E.t.j. Brabant, Thyroid hormones and the metabolic syndrome. 2013. 2(2): p. 83-92.
7. Han, C., et al., Subclinical hypothyroidism and type 2 diabetes: a systematic review and meta-analysis. 2015. 10(8): p. e0135233.
8. Lee, Y., et al., Plasma FGF21 levels are increased in patients with hypothyroidism independently of lipid profile. 2013. 60(8): p. 977-983.
9. MIYAKAWA, M., et al., Serum leptin levels and bioelectrical impedance assessment of body composition in patients with Graves' disease and hypothyroidism. 1999. 46(5): p. 665-673.
10. García-Bartolomé, A., et al., Altered expression ratio of actin-binding gelsolin isoforms is a novel hallmark of mitochondrial OXPHOS dysfunction. 2020. 9(9): p. 1922.
11. Liu, Y., H.-j. Yin, and K.-j.J.C.j.o.i.m. Chen, Research on the correlation between platelet gelsolin and blood-stasis syndrome of coronary heart disease. 2011. 17: p. 587-592.
12. Xue, M., K.-j. Chen, and H.-j.J.C.j.o.i.m. Yin, Relationship between platelet activation related factors and polymorphism of related genes in patients with coronary heart disease of blood-stasis syndrome. 2008. 14: p. 267-273.
13. Liu, Y., et al., Correlation between platelet gelsolin levels and different types of coronary heart disease. 2012. 57: p. 631-638.
14. Gao, Z.-y., et al., Analysis on outcome of 5284 patients with coronary artery disease: the role of integrative medicine. 2012. 141(2): p. 578-583.
15. Zhuang, M., et al., Determination of the level of cytoplasmic free calcium in human platelets with flow cytometry. 2004.
16. Grynkiewicz, G., M. Poenie, and R.Y.J.J.o.b.c. Tsien, A new generation of Ca2+ indicators with greatly improved fluorescence properties. 1985. 260(6): p. 3440-3450.
17. Patel, V.B., et al., PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease. 2018. 9(1): p. 5390.
18. Kułakowska, A., et al., Depletion of plasma gelsolin in patients with tick-borne encephalitis and Lyme neuroborreliosis. Neurodegener Dis, 2011. 8(5): p. 375-80.
19. Zhang, Q., et al., Role and therapeutic potential of gelsolin in atherosclerosis. 2023.
20. Hsieh, C.H. and Y.C. Wang, Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment. Kaohsiung J Med Sci, 2022. 38(9): p. 819-825.
21. Nuttall, F.Q.J.N.t., Body mass index: obesity, BMI, and health: a critical review. 2015. 50(3): p. 117.
22. DeUgarte, C.M., et al., Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. 2005. 83(5): p. 1454-1460.
23. Friedewald, W.T., R.I. Levy, and D.S.J.C.c. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. 1972. 18(6): p. 499-502.
24. Laurberg, P., et al., Screening for overt thyroid disease in early pregnancy may be preferable to searching for small aberrations in thyroid function tests. 2013. 79(3): p. 297-304.
25. Gaitonde, D.Y., K.D. Rowley, and L.B.J.S.A.F.P. Sweeney, Hypothyroidism: an update. 2012. 54(5): p. 384-390.
26. Shamitova, E. and I.J.E.J.o.N.H. Myasnikova, Clinical Case Of Hypothyroidism In A Patient With Autoimmune Thyroiditis. 2019(4): p. 27-29.
27. Chiovato, L., F. Magri, and A. Carlé, Hypothyroidism in Context: Where We've Been and Where We're Going. Adv Ther, 2019. 36(Suppl 2): p. 47-58.
28. Razvi, S., S. Bhana, and S.J.J.o.t.r. Mrabeti, Challenges in interpreting thyroid stimulating hormone results in the diagnosis of thyroid dysfunction. 2019. 2019.
29. Gierach, M., J. Gierach, and R. Junik, Insulin resistance and thyroid disorders. Endokrynol Pol, 2014. 65(1): p. 70-6.
30. Heidings, J.B., et al., Gelsolin-mediated actin filament severing in crowded environments. 2020. 532(4): p. 548-554.
31. Noren Hooten, N., et al., Plasma gelsolin levels are associated with diabetes, sex, race, and poverty. 2023. 21(1): p. 190.
32. K Sharma, A., et al., Hypothyroidism and cardiovascular disease: factors, mechanism and future perspectives. 2013. 20(35): p. 4411-4418.
33. Sue, L.Y. and A.M.J.F.i.e. Leung, Levothyroxine for the treatment of subclinical hypothyroidism and cardiovascular disease. 2020. 11: p. 591588.
34. Li, G.H., et al., Multifunctional roles of gelsolin in health and diseases. 2012. 32(5): p. 999-1025.
35. Liu, Y., H. Yin, and K.J.S.C.L.S. Chen, Platelet proteomics and its advanced application for research of blood stasis syndrome and activated blood circulation herbs of Chinese medicine. 2013. 56: p. 1000-1006.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.