New sulfamethoxazole derivatives contain 1,2,3-triazoline ring in Vitro antibacterial agents

Main Article Content

Hayder Ghanim Chfat
Ministry of Education, The General Directorate of Educational in Najaf Al-Ashraf, Najaf, Iraq

Ezzat Hussein Zimam
Department of Chemistry, Faculty of Science, Kufa University, Al-Najaf-Iraq

Keywords

1,2,3-triazoline, Sulfametoxazole, Antibacterial activity, Click chemistry, Alkyl chain

Abstract

Triazoles stand out among the heterocyclic nitrogen-containing chemicals for their exceptional pharmacological uses. In this study, 6 novel sulfamethoxazole-triazole derivatives were synthesized and their antibacterial activities were investigated. Using melting point and spectroscopic methods (1H and 13C NMR), the produced compounds were thoroughly analyzed. Compounds (9 and 12) showed the greatest efficacy against E. coli with an inhibitory zone of 18 μg/mL when the in vitro antibacterial activities of synthesized compounds were assessed against two bacterial strains, S. aureus and E. coli. In addition, compound (12) with a MIC value of 22 μg/mL.had the strongest antibacterial activity against Staphyloccocus aureus.

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Published
Jun 3, 2023
DOI: https://doi.org/10.47750/jptcp.2023.30.13.017

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How to Cite
Hayder Ghanim Chfat, & Ezzat Hussein Zimam. (2023). New sulfamethoxazole derivatives contain 1,2,3-triazoline ring in Vitro antibacterial agents. Journal of Population Therapeutics and Clinical Pharmacology, 30(13), 170-177. https://doi.org/10.47750/jptcp.2023.30.13.017
Issue
Vol. 30 No. 13 (2023): JPTCP
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Articles
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How to Cite

Hayder Ghanim Chfat, & Ezzat Hussein Zimam. (2023). New sulfamethoxazole derivatives contain 1,2,3-triazoline ring in Vitro antibacterial agents. Journal of Population Therapeutics and Clinical Pharmacology, 30(13), 170-177. https://doi.org/10.47750/jptcp.2023.30.13.017