Characteristics Of Patients with Grave's Disease with ECG Sick Node Dysfunction (SND) With History of Thyroidectomy and PTU Treatment
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Keywords
Graves Disease, SND, Thyroidectomy, PTU
Abstract
Background: Hyperthyroidism is an endocrine disorder with the second highest incidence after diabetes, and Graves' Disease is the most common cause of hyperthyroidism. About 60%-80% of hyperthyroidism cases are caused by Graves' disease where women in the age of 20-50 years are more dominant than men. Graves' disease is an autoimmune disorder, the presence of thyroid stimulating immunoglobulin (TSI), or can be called thyroid stimulating antibody (TSAb) secreted in the thyroid gland binds to thyroid stimulating hormone (TSH) receptors in the thyroid gland. Thus, stimulating the thyroid gland to work to produce thyroxine hormone based on stimulation from TSH receptors. Continuous stimulation of TSAb results in states of hyperthyroidism and thyroomegaly. Hyperthyroidism causes a weakened heart rate and ECG images that show sinus syndrome include sinus bradycardia (heart rate <40 bpm), sinus pause (sudden pause of sinus nodes shorter than 2-3 seconds), and sinus arrest (sudden pause of sinus nodes more than 2-3 seconds). PTU is one of the treatments carried out on grave's disease patients.
Objective: Know the characteristics of patients with Grave's Disease with ECG images of Sick Node Dysfunction (SND) with a History of Thyroidectomy and PTU Treatment.
Method: This research is a Systematic Review using the Preferred Reporting Items for Systematic Reviews and Meta-analyses method or commonly called PRISMA, this method is carried out systematically by following the correct research stages or protocols. Sources were taken from the PubMed site and Google Scholar site with journals published in 201 7-2022 and then screening results were obtained 15,486.
Results: Journal clustering was carried out and the number of journals indexed by Scopus Q1 was 2 journals, Q2 2 journals, indexed Sinta S1 1 journal, so that there were 5 journals extracted
Conclusion: The journal discusses age and lifestyle related to the characteristics of grave disease and grave disease risk factors determined based on age and sex and grave disease related to SND ECG images.
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