Study_some_of_hematological_parameters_changes_of_Iraqi_Acute_Myeloid
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Keywords
Acute myeloid leukemia, Hematological parameters, WBC count, Platelets count, Hemoglobin levels, Chemotherapy
Abstract
Objective: To assess the alterations in hematological indicators of Iraqi patients with acute myeloid leukemia before and post-chemotherapy.
Material and method: This is a case-control study of newly diagnosed acute myeloid leukemia (AML) cases in the Iraqi population diagnosed between February 2022 and November 2022 at the Iraqi Center for Hematology in the Medical City in Baghdad teaching hospital. Peripheral blood samples were taken from all participants. An automated hematology analyzer determined WBC, HB, and Platelet count. Blast cell% in the peripheral blood was estimated on Giemsa-stained blood smears. The blood film examination was done for WBC differential count. Mean and standard deviation was used for quantitative, while frequency and percentages were used for qualitative data.
Results: A total of 40 patients were newly diagnosed with AML, the majority of the patients were male, and the most common subtype of AML was Acute myeloblastic leukemia-M2. Most of the patients are between 51-61 (35%) years old. Most patients had leukocytosis, anemia, and thrombocytopenia, and blast cells were present in the peripheral blood of 90% of the AML patients. The results also showed a significant increase in WBC count and a significant decrease in platelet count and hemoglobin concentrations in AML patients compared to healthy controls. A significant decrease was observed in most of the hematological parameters after Chemotherapy.
Conclusion: In this study, all patients with AML have abnormal levels of all hematological parameters. The patients who received Chemotherapy show different levels of these parameters, such as WBC, HB, Platelet count and Blast cells. It is obvious that AML has a strong impact on the hematological parameters.
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