Study of IL-27 Polymorphisms with Chemical Factor in Abortion Women

Abstract

Disease-predictive single nucleotide polymorphisms (SNPs) are also found in cytokines, which are under the control of genetics and whose genetic variations operate to modulate the amounts of cytokine gene expression. Its objectives are. in women who have had abortions, limited polymorphism of il27 with free any pathogen. whole samples were taken from the Women's and Children's Hospital in the city of Hilla and the Women's Hospital in the city of Dhi-Qar The total number of samples was 200 divided into four groups: the first group is women who suffer from miscarriage in the first trimester, the second group is women who suffer from miscarriage in the second trimester, the third group who suffer from miscarriage in the third trimester, and the last group are women who are only pregnant. for detecting the level of IL-27 by ELISA while the allelic discrimination method was used for SNP IL-27. The results indicated the IL-27 serum concentration elevated with significant differences in recurrent abortion in both groups compared to healthy women, Also, recurrent abortion had significant differences compared to healthy women (P<0.05). Also, in recurrent abortion, the level of IL-27 for, GC, and CC genotypes showed significant differences compared to healthy and pregnant women (P<0.05). Also, in recurrent abortion, the level of IL-27In conclusion, the level of IL-27 in recurrent abortion women with free pathogen was higher than the recurrent abortion women, which may be due to the pro-inflammatory for l27. SNP of IL-27 has been represented as a risk factor in recurrent abortion women.