Tissue Microrna As a Potential Biomarker in Oral Squamous Cell Carcinoma - A Systematic Review
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Keywords
miRNA, Oral Squamous Cell Carcinoma, Biomarker
Abstract
Background: Oral squamous cell carcinoma is the most common form of carcinoma of the oral cavity and ranks as the 12th most common cancer in the world. Cancer development and progression requires inactivation of tumour suppressor gene and activation of proto-oncogenes. Expression of these genes is in part dependent on RNA –based mechanisms. MicroRNAs are essential regulators of diverse cellular processes including proliferation, differentiation ,apoptosis ,survival, motility , invasion and morphogenesis
Aim: To evaluate the differential expression of tissue miRNAs in OSCC tissue samples and their use as biological markers to predict the prognosis of OSCC patients.
Methods: A search was done using MeSH terms and keyword search in the electronic databases namely PubMed, Google Scholar, Cochrane, Science Direct ,Lilacs and additional searches were carried out through cross checking the bibliographies of selected articles. Then based on the inclusion and exclusion criteria and availability of the full texts, a total of 2 articles were included in this systematic review
Result: The search yielded a total of articles out of which 56 articles were included based on the eligibility criteria. Quality assessment based on the Quality Assessment of Diagnostic Accuracy Studies 2 tool was used to obtain a risk of bias chart using Revman 5.4 software and it was proved that from the 2 included studies, one had low risk of bias and another had moderate risk of bias.
Conclusion: This systematic review aimed at improving the current understanding of next generation sequencing and applicability in OSCC. Further, this may be an alleyway for the identification of newer biomarkers using NGS-based technique.
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