Cancer Prognosis & Stratification with Sentimental Analysis using Deep Learning and Machine Learning Techniques

Main Article Content

R.Yamini
Shiven Sharma
Ayush Sachdeva

Keywords

Machine learning, deep learning, multiple cancer prediction, data augmentation, analysis, data visualization, decision tree, random forest, artificial neural networks, supervised machine learning, ensemble models

Abstract

For therapy and monitoring, it is crucial to provide prognostic information at the time of cancer diagnosis. Even while factors including cancer staging, histopathological evaluation, genetic characteristics, and clinical variables might offer helpful prognostic clues, risk stratification still has to be improved. All these data generate defined patterns and those patterns can be examined with the help of Machine Learning and Deep Learning. The most promising algorithm for this use case is artificial neural networks. Decision trees might be used to the best extent as they provide an adequate balance of speed and accuracy. An ideal approach would be through the effective combination of ANN and Random Forests. Ensembling models would also be able to boost the performance of the system. The metrics and scores for the project must be in-scope of the development and at the same time extendable.

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References

1. Weiser MR, Gönen M, Chou JF, Kattan MW, Schrag D. Predicting survival after curative colectomy for cancer: individualizing colon cancer staging. J Clin Oncol. 2011;29: 4796–4802. pmid:22084366
2. Cooperberg MR, Pasta DJ, Elkin EP, Litwin MS, Latini DM, Du CHANE J, et al. The University of California, San Francisco Cancer of the Prostate Risk Assessment score: a straightforward and reliable preoperative predictor of disease recurrence after radical prostatectomy. Journal of Urology. 2005. pp. 1938–1942. pmid:15879786
3. Sparano JA, Gray RJ, Ravdin PM, Makower DF, Pritchard KI, Albain KS, et al. Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer. N Engl J Med. 2019. pmid:31157962
4. Sparano JA, Gray RJ, Makower DF, Pritchard KI, Albain KS, Hayes DF, et al. Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer. N Engl J Med. 2018;379: 111–121. pmid:29860917
5. Rakha EA, El-Sayed ME, Lee AHS, Elston CW, Grainge MJ, Hodi Z, et al. Prognostic significance of Nottingham histologic grade in invasive breast carcinoma. J Clin Oncol. 2008;26: 3153–3158. pmid:18490649
6. LeCun Y, Bengio Y, Hinton G. Deep learning. Nature. 2015;521: 436–444. pmid:26017442
7. Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, et al. Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs. JAMA. 2016;316: 2402–2410. pmid:27898976
8. Ehteshami Bejnordi B, Veta M, Johannes van Diest P, van Ginneken B, Karssemeijer N, Litjens G, et al. Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer. JAMA. 2017;318: 2199–2210. pmid:29234806
9. Liu Y, Kohlberger T, Norouzi M, Dahl GE, Smith JL, Mohtashamian A, et al. Artificial Intelligence-Based Breast Cancer Nodal Metastasis Detection. Arch Pathol Lab Med. 2018. pmid:30295070
10. Nagpal K, Foote D, Liu Y, Chen P-HC, Wulczyn E, Tan F, et al. Development and validation of a deep learning algorithm for improving Gleason scoring of prostate cancer. npj Digital Medicine. 2019;2: 48. pmid:31304394
11. Saltz J, Gupta R, Hou L, Kurc T, Singh P, Nguyen V, et al. Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images. Cell Rep. 2018;23: 181–193.e7.