Role Of Serum Zinc Level and Its Supplementation In Children With Febrile Seizures
Main Article Content
Keywords
serum zinc, febrile seizure, Children
Abstract
Aim of study: This study aims to determine the role of serum zinc level as a triggering factor for febrile seizure in Children and its value for better management.
Methods: This study involved 90 kids aged 6 months to 6 years who had 30 simple and 30 complex febrile seizures and were patients at Al-Zahra University Hospital. Her 30 children, who were the same age and sex, served as the study's control group. A comprehensive medical history, clinical assessments of the general and neurological systems, and measurements of the serum zinc levels were all performed on each subject.
Results: There was a highly statistically significant difference (p 0.000) in serum zinc levels between the patient and control groups after zinc supplementation, with the difference being higher in the complex group and between the simple and complex groups. The frequency of seizures dropped.
Conclusion: Zinc has been implicated in the development of febrile seizures and is beneficial for measurement in children with febrile seizures.
References
2. Amneenah AM, Alqatani HAH. Association between Serum Zinc level and Febrile Seizures. The Egyptian Journal of Hospital Medicine .July 2022; Vol. 88, Page 2288-2292
3. Arul J, Kommu PPK, Kasinathan A, et al. Zinc Status and Febrile Seizures: Results from a Cross-sectional Study. J Neurosci Rural Pract. 2020 Oct;11(4):597-600. doi: 10.1055/s-0040-1715992. Epub 2020 Sep 8. PMID: 33144797; PMCID: PMC7595794.
4. De Benoist B, Darnton-Hill I, Davidsson L, et al. Conclusions of the joint WHO/UNICEF/IAEA/IZiNCG interagency meeting on zinc status indicators. Food Nutr Bull.2007; 3:480– 484.
5. Debroy P , Baruah A. Serum Zinc and Magnesium Levels in Children with Febrile Seizure: A Hospital Based Cross-Sectional Study.2021
6. Fallah R, Sabbaghzadegan S, Karbasi SA, et al. Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: a randomised clinical trial. Nutrition.2015; 31:1358–1361.
7. Heydarian F, Nakhaei AA, Majd HM, et al. Zinc deficiency and febrile seizure: a systematic review and meta-analysis. Turk J Pediatr. 2020;62(3):347-358. doi: 10.24953/turkjped.2020.03.001. PMID: 32558408.
8. Hosseini, F., Nikkhah, A., And Goli,A. (2020). Serum zinc level in children with febrile seizure. Iranian Journal of Child Neurology,; 14(1), 43.
9. Kumar L , Chaurasiya O, Gupta A. Prospective study of level of serum zinc in patients of febrile seizures, idiopathic epilepsy and CNS infections. People’s Journal of Scientific Research.2011; 4(2): 1-4.
10. Leung AK, Hon KL, Leung TN. Febrile seizures: an overview. Drugs Context. 2018 Jul 16;7:212536. doi: 10.7573/dic.212536. PMID: 30038660; PMCID: PMC6052913.
11. Mahmoud AT, Albassuoni MA, Abd El Nabi SA, et al. Serum zinc and iron levels in children with febrile seizures. Menoufia Med J 2021;34:611-6
12. Mahmoud T , Albassuoni A , Abd El Nabi A,et al. Serum zinc and iron levels in children with febrile seizures. Menoufia Medical Journal.2021; 34(2), 611.
13. Margaretha L, Masloman N. Correlation between serum Zinc level and simple febrile seizure in children. Pediatr Indon.2020; 50:326– 330
14. Mosili P, Maikoo S, Mabandla MV, et al. The Pathogenesis of Fever-Induced Febrile Seizures and Its Current State. Neurosci Insights. 2020 Nov 2;15:2633105520956973. doi: 10.1177/2633105520956973. PMID: 33225279; PMCID: PMC7649866.
15. Okposio M , Sadoh W , Ofovwe G , et al. Serum zinc level in nigerian children with febrile convulsion. Journal of Pediatric Neurology.2012; 10: 187-191.
16. Sampathkumar P, Kannan KS. A comparative study of serum zinc levels in children with febrile seizures and children with fever without seizures in an urban referral hospital. Int J Contemp Pediatric.2018; 5:977-982.
17. Sampathkumar P, Kannan KS. A comparative study of serum zinc levels in children with febrile seizures and children with fever without seizures in an urban referral hospital. Int J Contemp Pediatric.2018; 5:977-982.
18. Tamilarasu N , Kumaravel S , Ramesh Babu B . A Study of Serum Zinc Levels in Children with Febrile Seizures in a Referral Hospital.2020
19. Whelan H , Harmelink M , Chou E , et al. Complex febrile seizures—a systematic review. Disease-a-Month.2017; 63(1), 5-23.