Relationship between Leukotriene B4 (LTB4) and the pathogenicity of Trichomonas vaginalis
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Keywords
Trichomonas vaginalis, Trichomonasiasis, Leukotriene B4
Abstract
Trichomonasis, which is brought on by the parasite Trichomonas vaginalis, is the most prevalent non-viral, curable worldwide sexually transmitted disease that affects millions of individuals every year. Numerous immunological and biochemical elements were discovered to be involved in the pathogenesis of T. vaginalis. In our study, we sought to determine how T. vaginalis virulence and leukotriene B4 (LTB4) interact. 350 women (15–65 year) who visited a women's and gynecological hospital in Karbala between November 2021 and June 2022 for this study provided swabs of vagina, samples of urine and samples of blood took place. Routine urine analysis and examination of by direct microscopic to vaginal swabs were used to identify parasites, and its ELISA approach was used to calculate serum (LTB4) levels. Participating women filled out a questionnaire that asked about their age, place of residence, marital status, degree of education, reproductive potential, and use of contraception. As a result, only 100 of the 350 cases tested positive for T. vaginalis, with an age group (15–24 year) having the highest frequency and the age group 65+ having the lowest incidence (15-24). 55 years). -65) years. By educational background, 18 women (28.57%) were illiterate, 22 (29.33%) in primary education, 42 (28.18%) in secondary education, and 18 (28.57%) in bachelor level. They did not differ significantly from one another (P=0.998). In healthy, non-patient-infected women, the mean and standard deviation of serum (LTB4) were 19.14 and 7.14, respectively, but in patient-infected women, they were (96.41 and 25.9). did. (P 0.001) Significant difference. We can infer from the current study that women who had T. vaginalis infections had significantly higher serum levels of LTB4.
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