Outcomes of COVID 19 patients with acute kidney injury in Thi Qar province, south of Iraq
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Keywords
COVID-19; Acute Kidney Injury; Recovery ;dialysis and mortality
Abstract
Background: Acute kidney injury (AKI) has been associated with an increased mortality rate among hospitalized patients with Coronavirus disease 2019 (COVID-19). However, AKI among hospitalized patients with COVID-19 is not well described.
Methods: In this retrospective cohort study, we enrolled adult patients who were referred to AlHussein Teaching Hospital in Thi-Qar Governorate, Iraq, from 15 February to 15 May 2020, diagnosed with Corona Varus by Real-Time polymerase chain reaction (PCR) A test with a diagnosis of COVID. -19. AKI was determined according to the outcome criteria for creatinine determination and Introduced by the KDIGO in 2012. Patients were stratified based on recovery, dialysis, and hospital mortality. We also assessed risk indicators associated with AKI during hospitalization along with in-hospital outcomes, recovery rate, and death at the time of discharge. And after three months of going out for both sexes.
Results: We evaluated 2044 patients, whose ages ranged from 18 to more than 65 years, for both males and females, and the percentage of males 54.7% and females 45.3% were admitted with a diagnosis of COVID-19. AKI occurred in 194(8.02%) patients; 55(35.5%) of the patients with AKI required dialysis. It was observed that 43.1% of males recovered to 43.8% of the females who were
cured inside the hospital, and there was a percentage of patients Those who needed dialysis, and there was a percentage of deaths among males and females. Patients with AKI showed a significantly higher mortality rate. The patients’ condition was followed up after their discharge from the hospital, and the percentage of those who were cured and the patients who needed dialysis was determined, and the rate and mortality.
conclusion: We found that male sex, patients' ages, history of chronic kidney disease, and disease severity were independent risk factors associated with AKI in COVID-19 patients. Whereas, acute renal insufficiency was associated with an increased risk of death, increased dialysis patients, and inhospital complications. Our results indicate the need for more careful care and monitoring of AKI
during hospitalization in patients with COVID-19, and non-recovery of acute renal impairment on hospital discharge is a common complication in these patients.
References
2. Bonventre, J. V., & Yang, L. (2011). Cellular pathophysiology of ischemic acute kidney injury. The Journal of clinical investigation, 121(11), 4210-4221.
3. Chan L, Chaudhary K, Saha A, Chauhan K, Vaid A, Shan Z, et al (2020). AKI in hospitalized patients with COVID-19. J Am Soc Nephrol.;32:151–60.
4. Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., et al. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel
coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395, 507–513. doi: 10.1016/s0140-6736(20)30211-7
5. Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al(2020). Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int.;97((5)):829–38.
6. Chong, S., Huang, Y., & Chang, C. H. D. (2020). Supporting interdependent telework employees: A moderated-mediation model linking daily COVID-19 task setbacks to next-day work withdrawal. Journal of Applied Psychology, 105(12), 1408.
7. Coca SG, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Krumholz HM, et al(2014).; for the TRIBE-AKI Consortium : Urinary biomarkers of AKI and mortality 3 years after cardiac surgery. J Am Soc Nephrol 25: 1063–1071.
8. Fu, L., Wang, B., Yuan, T., Chen, X., Ao, Y., Fitzpatrick, T., ... & Zou, H. (2020). Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis. Journal of Infection, 80(6), 656- 665.
9. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al(2020). Clinical characteristics of coronavirus disease 2019 in China. N Engl J
Med.;382((18)):1708–20.
10. Guan, W. J., Ni, Z. Y., Hu, Y., Liang, W. H., Ou, C. Q., He, J. X., et al. (2020). Clinical characteristics of Coronavirus Disease 2019 in
China. N. Engl. J. Med. 382, 1708–1720.
11. Gupta S, Hayek SS, Wang W, et al(2020). Factors associated with death in critically ill patients with coronavirus disease 2019 in the US. JAMA Intern Med.;180(11):1436–1446.
12. Hansrivijit P et al (2020). Incidence of acute kidney injury and its association with mortality in patients with COVID-19: a metaanalysis. J Investig Med. https://doi.org/10.1136/jim-2020- 00140.
13. Khwaja A. (2012). KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract.;120(4):c179-84. doi: 10.1159/000339789. Epub 2012 Aug 7. PMID: 22890468.
14. Kunutsor SK, Laukkanen JA (2020). Renal complications in COVID-19: a systematic review and meta-analysis. Ann Med.
https://doi.org/10.1080/07853890.2020.1790643
15. Lumlertgul N, Pirondini L, Cooney E, et al(2021). Acute kidney injury prevalence, progression and long-term outcomes in critically ill patients with COVID-19: a cohort study. Ann Intensive Care.;11(1):123.
16. Nugent J, Aklilu A, Yamamoto Y, et al(2021). Assessment of acute kidney injury and longitudinal kidney function after hospital
discharge among patients with and without COVID-19. JAMA Netw Open.;4(3):e211095.
17. Pei, G., Zhang, Z., Peng, J., Liu, L., Zhang, C., Yu, C., et al. (2020). Renal involvement and early prognosis in patients with COVID-19 pneumonia. J. Am. Soc. Nephrol. 31, 1157–1165. doi: 10.1681/asn.2020030276.
18. Ronco C, Reis T, Husain-Syed F (2020). Management of acute kidney injury in patients with COVID-19. Lancet Respir Med 8:738–742.
https://doi.org/10.1016/s2213-2600(20)30229-0.
19. Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., et al. (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel
coronavirus-infected pneumonia in Wuhan, China. JAMA 323, 1061–1069. doi: 10.1001/jama.2020.1585
20. Yan Q et al (2020). Acute kidney injury is associated with inhospital mortality in older patients with COVID-19. J Gerontol Ser A Biol
Sci Med Sci. https://doi.org/10.1093/gerona/glaa181
21. Zahid U, Ramachandran P, Spitalewitz S, Alasadi L, Chakraborti A, Azhar M, et al. (2020). Acute kidney injury in COVID-19 patients: an inner city hospital experience and policy implications. Am J Nephrol.;51((10)):786–96.
22. Zhang NH, Cheng YC, Luo R, Zhang CX, Ge SW, Xu G.( 2021). Recovery of new-onset kidney disease in COVID-19 patients discharged from hospital. BMC Infect Dis.;21(1):397.
23. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al.( 2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in
Wuhan, China: a retrospective cohort study. Lancet.;395((10229)):1054–62.
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