An exploratory study to know the effects of Helicobacter pylori on (Hepatitis C Virus) patients in Iraq

Main Article Content

Sabah Ali Jaber Alhelu
Ministry of Higher Education and Scientific Research, College of Medicine, Jabir Ibn Hayyan Medical University, Al-Najaf, Iraq

Suhair Sadai Mahmood
Ministry of Higher Education and Scientific Research, Medical College, Al-Iraqia University, Baghdad, Iraq

Khaleel Ibrahim Ismael
Department of Clinical Reproductive Physiology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Nahrain University, Kadhimiya, Baghdad, Iraq

Abbas AbdulWahhab Jumaah
Department of Applied Embryology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Nahrain University, Kadhimiya, Baghdad, Iraq

Ban Thabit Saeed
Department of Applied Embryology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Nahrain University, Kadhimiya, Baghdad, Iraq

Luai Farhan Zghair
Ministry of Higher Education and Scientific Research, Surgical Department, Medical College, Al-Iraqia University, Baghdad, Iraq

Ali Qais Abdulkafi
raqi Ministry of Health, Kirkuk Health Department, Kirkuk General Hospital, Kirkuk, Iraq

Keywords

Helicobacter; pylori; Hepatitis C virus; BMI; microaerophilic

Abstract

This study aims to investigate the effects of Helicobacter pylori on hepatitis C virus (HCV) patients in Iraq. The demographic data and information were gathered from various hospitals to study 35 cases, under two groups, H. pylori+ (20 patients) and H. pylori− (15 patients). The statistical relationships were analysed using the IBM SOFT SPSS 25 data analysis programme, to know the effect of H. pylori on HCV patients in Iraq and were represented by mean SD. The mean SD to the age of the patients participating in this study was 44+ 8.2 and a higher BMI was observed in H. pylori+ patients (30.33 ± 2.9). The patients were distributed based on the severity of fibrosis into two groups: no cirrhosis for 10 patients (P% = 28.5%) and HCV for 25 patients (P%= 71.42%). The mean + SD for the no-fibrosis group was 4.4 + 1.2 and the HCV group was 12.9+ 5.5. The study found a statistically significant relationship between H. pylori and HCV patients at a level of 0.0023 with R corrections of 0.083.

Abstract 349 | pdf Downloads 249

References

1. Niemela S, Karttunen T, Heikkila J, Maentausta O, Lehtola J. Relationship of Campylobacter pylori and duodenogastric reflux. Dig Dis Sci. 1989;34:1021–4. https://doi.org/10.1007/BF01536367
2. Kellosalo J, Alavaikko M, Laitinen S. Effect of biliary tract procedures on duodenogastric reflux and the gastric mucosa. Scand J Gastroenterol. 1991;26:1272–8. https://doi.org/10.3109/00365529108998624
3. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, et al. Histological grading and staging of chronic hepatitis. J Hepatol. 1995;22:696–9. https://doi.org/10.1016/0168-8278(95)80226-6
4. Linz B, Balloux F, Moodley Y, Manica A, Liu H, Roumagnac P, et al. An African origin for the intimate association between humans and
Helicobacter pylori. Nature. 2007;445(7130):915–8.https://doi.org/10.1038/nature05562
5. Marshall BJ, Barrett LJ, Prakash C, McCallum RW, Guerrant RL. Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect
of acid. Gastroenterology. 1990;99(3):697–702.https://doi.org/10.1016/0016-5085(90)90957-3
6. Nejati S, Karkhah A, Darvish H, Validi M, Ebrahimpour S, Nouri HR. Influence of Helicobacter pylori virulence factors CagA and VacA on the
pathogenesis of gastrointestinal disorders. Microb Pathog. 2018;117:43–48.https://doi.org/10.1016/j.micpath.2018.02.016
7. Ward JM, Anver MR, Haines DC, Benveniste RE. Chronic active hepatitis in mice caused by Helicobacter hepaticus. Am J Pathol.
1994;145(4):959–68.
8. Abdel-Hady H, Zaki A, Badra G, Lotfy M, Selmi C, Giorgini A, et al. Helicobacter pylori infection in hepatic encephalopathy: Relationship to plasma endotoxins and blood ammonia. Hepatol Res. 2007;37:1026–33. https://doi.org/10.1111/j.1872-
034X.2007.00146.x
9. Graham DY. Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer. Gastroenterology. 1997;113:1983–6.
https://doi.org/10.1016/S0016-5085(97)70019-2
10. de Magalhaes Queiroz DM, Santos A. Isolation of a Helicobacter strain from the human liver. Gastroenterology. 2001;121(4):1023–4.
https://doi.org/10.1053/gast.2001.28574
11. Dooley CP, Cohen H, Fitzgibbons PL, Bauer M, Appleman MD, Perez-Perez GI, et al. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med. 1989;321:1562–6. https://doi.org/10.1056/NEJM198912073212302
12. Asaka M, Kimura T, Kudo M, Takeda H, Mitani S, Miyazaki T, et al. Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology. 1992;102:760–6. https://doi.org/10.1016/0016-5085(92)90156-S
13. Youn HS, Ko GH, Chung MH, Lee WK, Cho MJ, Rhee KH. Pathogenesis and prevention of stomach cancer. J Kor Med Sci. 1996;11:373–85.
https://doi.org/10.3346/jkms.1996.11.5.373
14. Rocha M, Avenaud P, Menard A, Le Bail B, Balabaud C, Bioulac-Sage P, et al. Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma. Gut. 2005;54:396–401. https://doi.org/10.1136/gut.2004.042168
15. Spinzi G, Pellicano R, Minoli G, Terreni N, Cutufia M, Fagoonee S, et al. Helicobacter pyloriseroprevalence in hepatitis C virus-positive patients with cirrhosis: The Como cross-sectional study. Panminerva Med. 2001;43:85–7.
16. Queiroz DM, Rocha AM, Rocha GA, Cinque SM, Oliveira AG, Godoy A, et al. Association between Helicobacter pylori infection and cirrhosis in patients with chronic hepatitis C virus. Dig Dis Sci. 2006;51:370–3. https://doi.org/10.1007/s10620-006-3150-y
17. Ponzetto A, Pellicano R, Leone N, Cutufia MA, Turrini F, Grigioni WF, et al. Helicobacter infection and cirrhosis in hepatitis C virus carriage: Is it an innocent bystander or a troublemaker? Med Hypotheses. 2000;54:275–7. https://doi.org/10.1054/mehy.1999.0987
18. Balkwill F, Mantovani A. Inflammation and cancer: Back to Virchow? Lancet. 2001;357:539–45. https://doi.org/10.1016/S0140-6736(00)04046-0

Article Sidebar

pdf
Published
Feb 11, 2023
DOI: https://doi.org/10.47750/jptcp.2023.1056

Article Details

How to Cite
Sabah Ali Jaber Alhelu, Suhair Sadai Mahmood, Khaleel Ibrahim Ismael, Abbas AbdulWahhab Jumaah, Ban Thabit Saeed, Luai Farhan Zghair, & Ali Qais Abdulkafi. (2023). An exploratory study to know the effects of Helicobacter pylori on (Hepatitis C Virus) patients in Iraq. Journal of Population Therapeutics and Clinical Pharmacology, 30(2), 43-49. https://doi.org/10.47750/jptcp.2023.1056
Issue
Vol. 30 No. 2 (2023): JPTCP
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All articles published in JPTCP  are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Sabah Ali Jaber Alhelu, Suhair Sadai Mahmood, Khaleel Ibrahim Ismael, Abbas AbdulWahhab Jumaah, Ban Thabit Saeed, Luai Farhan Zghair, & Ali Qais Abdulkafi. (2023). An exploratory study to know the effects of Helicobacter pylori on (Hepatitis C Virus) patients in Iraq. Journal of Population Therapeutics and Clinical Pharmacology, 30(2), 43-49. https://doi.org/10.47750/jptcp.2023.1056

Most read articles by the same author(s)